THE EXPRESSION OF GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR IN ACTIVATED MOUSE LYMPHOCYTES DECLINES WITH AGE

被引：19

作者：

CAI, NS ^{[1
]}

LI, DD ^{[1
]}

CHEUNG, HT ^{[1
]}

RICHARDSON, A ^{[1
]}

机构：

[1] ILLINOIS STATE UNIV,DEPT CHEM,NORMAL,IL 61761

来源：

CELLULAR IMMUNOLOGY | 1990年 / 130卷 / 02期

关键词：

D O I：

10.1016/0008-8749(90)90274-U

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The expression of granulocyte/macrophage colony-stimulating factor (GM-CSF) was studied in spleen lymphocytes isolated from male C57BL/6J mice of 6, 20, and 29 months of age. GM-CSF expression (biological activity and mRNA level) was maximum after culturing the lymphocytes for 45 hr with concanavalin A and phorbol myristate acetate. The induction of both GM-CSF activity and mRNA levels was observed to decline over 60% between 6 and 29 months of age. The age-related decline in the level of GM-CSF paralleled the age-related decline in the mRNA levels of interleukin-2 and interleukin-3. © 1990.

引用

页码：311 / 319

页数：9

共 47 条

[21] PROLIFERATIVE AND CYTO-TOXIC IMMUNE FUNCTIONS IN AGING MICE .3. EXOGENOUS INTERLEUKIN-2 RICH SUPERNATANT ONLY PARTIALLY RESTORES ALLOREACTIVITY INVITRO
GOTTESMAN, SRS
WALFORD, RL
THORBECKE, GJ
[J]. MECHANISMS OF AGEING AND DEVELOPMENT, 1985, 31 (02) : 103 - 113
[22] MOLECULAR-CLONING OF CDNA-ENCODING A MURINE HEMATOPOIETIC GROWTH-REGULATOR, GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR
GOUGH, NM
GOUGH, J
METCALF, D
KELSO, A
GRAIL, D
NICOLA, NA
BURGESS, AW
DUNN, AR
[J]. NATURE, 1984, 309 (5971) : 763 - 767
[23] RETRACTED: INTERLEUKIN-1 STIMULATES LYMPHOCYTES-T TO PRODUCE GRANULOCYTE-MONOCYTE COLONY-STIMULATING FACTOR (Retracted Article)
HERRMANN, F
OSTER, W
MEUER, SC
LINDEMANN, A
MERTELSMANN, RH
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1988, 81 (05) : 1415 - 1418
[24] Ihle J N, 1987, Adv Exp Med Biol, V213, P149
[25] ISOLATION OF CDNA FOR A HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR BY FUNCTIONAL EXPRESSION IN MAMMALIAN-CELLS
LEE, F
YOKOTA, T
OTSUKA, T
GEMMELL, L
LARSON, N
LUH, J
ARAI, KI
RENNICK, D
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (13) : 4360 - 4364
[26] LI DD, 1988, LIFE SCI, V43, P1215
[27] LINDEMANN A, 1988, J IMMUNOL, V140, P837
[28] MAYER P, 1987, ANN NY ACAD SCI, V511, P39
[29] ANALYSIS OF SINGLE-STRANDED AND DOUBLE-STRANDED NUCLEIC-ACIDS ON POLYACRYLAMIDE AND AGAROSE GELS BY USING GLYOXAL AND ACRIDINE-ORANGE
MCMASTER, GK
CARMICHAEL, GG
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (11) : 4835 - 4838
[30] THE CELL BIOLOGY OF AGING - IMMUNOLOGICAL MODELS
MILLER, RA
[J]. JOURNALS OF GERONTOLOGY, 1989, 44 (01): : B4 - B8

← 1 2 3 4 5 →