THE INVOLVEMENT OF FREE-RADICALS IN THE MECHANISMS OF MONOOXYGENASES

被引：72

作者：

WHITE, RE

机构：

[1] Department of Drug Metabolism, The Bristol-Myers Squibb, Pharmaceutical Research Institute, Princeton

来源：

PHARMACOLOGY & THERAPEUTICS | 1991年 / 49卷 / 1-2期

关键词：

D O I：

10.1016/0163-7258(91)90020-M

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The occurrence of free radicals in the mechanisms of monooxygenases reflects the chemistry of dioxygen and the inertness of typical substrates. Thus, oxidation of such substrates requires attack by reduced dioxygen-derived free radicals. Consequently, a molecule of NAD(P)H must be invested for each substrate molecule oxidized. Furthermore, since free radicals are difficult to control, deviations from the intended reaction course are frequent. These considerations are illustrated by examination of the generation and fate of enzyme- and substrate-derived free radicals at various stages in the catalytic cycles of two monooxygenases important in xenobiotic biotransformation, dopamine beta-hydroxylase and cytochrome P-450.

引用

页码：21 / 42

页数：22

共 118 条

[61]

LARROQUE C, 1986, J BIOL CHEM, V261, P1083

[62] 4-ALKYL RADICAL EXTRUSION IN THE CYTOCHROME-P-450-CATALYZED OXIDATION OF 4-ALKYL-1,4-DIHYDROPYRIDINES [J].