THE 5' SEQUENCE OF HUMAN FACTOR-XII GENE CONTAINS TRANSCRIPTION REGULATORY ELEMENTS TYPICAL OF LIVER SPECIFIC, ESTROGEN-MODULATED GENES

被引：23

作者：

CITARELLA, F

MISITI, S

FELICI, A

AIUTI, A

LAPORTA, C

FANTONI, A

机构：

[1] Dipartimento di Biopatologia Umana, Sezione di Biologia Cellulare, Università di Roma 'La Sapienza', Roma

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1993年 / 1172卷 / 1-2期

关键词：

FACTOR-XII; LIVER; ESTROGEN; FIBRINOLYSIS; PROMOTER;

D O I：

10.1016/0167-4781(93)90294-N

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The human Factor XII gene codes for a serine proteinase synthesized in liver that activates both the coagulation and the fibrinolytic cascades. The nucleotide sequence analysis of a HincII-HincII 3129 bp fragment was performed showing that the FXII promoter region contains neither CAAT and TATA regulatory elements, nor GC islands, but revealing the presence of two tandemly repeated sequences in opposite orientation, two LF-A1 elements typical of the liver specific genes and one estrogen responsive element, that substantiates the observation of Factor XII gene modulation by estrogens.

引用

页码：197 / 199

页数：3

共 12 条

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