IDENTIFICATION OF SUBSTANCES FORMED BY DECOMPOSITION OF PEAK E-SUBSTANCE IN TRYPTOPHAN

被引：20

作者：

ITO, J ^{[1
]}

HOSAKI, Y ^{[1
]}

TORIGOE, Y ^{[1
]}

SAKIMOTO, K ^{[1
]}

机构：

[1] SHOWA DENKO CO LTD,LIFE SCI RES LAB,TOKYO,JAPAN

来源：

FOOD AND CHEMICAL TOXICOLOGY | 1992年 / 30卷 / 01期

关键词：

D O I：

10.1016/0278-6915(92)90139-C

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Peak E substance, a trace impurity in L-tryptophan, has been associated epidemiologically with an outbreak of eosinophilia-myalgia syndrome (EMS) in the USA in 1989. After fractionation and purification of this substance, nuclear magnetic resonance and fast-atom-bombardment mass spectroscopy were used to identify the molecular structures of peak X/X' (formed by the decomposition of peak E substance in a simulated gastric fluid) and peak Y/Y' substances (which are believed to be the intermediates in the transformation of peak E substance to peak X/X' substances). The analyses were also performed on synthesized peak E substance obtained from the reaction of tryptophan with acetaldehyde. The results indicated that the synthesized substance was of high purity and was suitable for use in studies investigating the relationship between peak E substance and EMS onset.

引用

页码：71 / 81

页数：11

共 6 条

[1] AN INVESTIGATION OF THE CAUSE OF THE EOSINOPHILIA-MYALGIA SYNDROME ASSOCIATED WITH TRYPTOPHAN USE [J].