HOMEOBOX TRANSCRIPTION FACTOR REGULATION IN THE CARDIOVASCULAR-SYSTEM

被引：28

作者：

GORSKI, DH ^{[1
]}

PATEL, CV ^{[1
]}

WALSH, K ^{[1
]}

机构：

[1] CASE WESTERN RESERVE UNIV,SCH MED,DEPT PHYSIOL & BIOPHYS,CLEVELAND,OH 44106

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 1993年 / 3卷 / 05期

关键词：

D O I：

10.1016/1050-1738(93)90004-P

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Tissue remodeling and alterations in cellular differentiation occur in the cardiovascular system during normal development and pathologic conditions such as cardiac hypertrophy and atherosclerosis. Homeobox genes encode transcription factors that have been shown to be regulators of body-plan formation, cell growth, differentiation, and region-specific cell migration in developing embryos. Recently, several homeobox genes have been either isolated from or detected in cardiovascular tissues, and evidence suggests that some of them may have a regulatory function in the cardiovascular system. We review here what is known about the role of homeobox transcription factors in the control of development and gene expression in the cardiovascular system.

引用

页码：184 / 190

页数：7

共 45 条

[1] THE ONCOGENIC POTENTIAL OF AN ACTIVATED HOX-2.4 HOMEOBOX GENE IN MOUSE FIBROBLASTS [J].

ABERDAM, D ;

NEGREANU, V ;

SACHS, L ;

BLATT, C .

MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (01) :554-557

[2]

BODMER R, 1990, DEVELOPMENT, V110, P661

[3]

BODMER R, 1993, DEVELOPMENT, V118, P719

[4] APTEROUS IS A DROSOPHILA LIM DOMAIN GENE REQUIRED FOR THE DEVELOPMENT OF A SUBSET OF EMBRYONIC MUSCLES [J].

BOURGOUIN, C ;

LUNDGREN, SE ;

THOMAS, JB .

NEURON, 1992, 9 (03) :549-561

[5]

CAMPBELL GR, 1987, VASCULAR SMOOTH MUSC, V1, P39

[6] FUNCTION OF THE HOMEODOMAIN PROTEIN GHF1 IN PITUITARY CELL-PROLIFERATION [J].

CASTRILLO, JL ;

THEILL, LE ;

KARIN, M .

SCIENCE, 1991, 253 (5016) :197-199

[7] ANTITHETICAL ACCUMULATION OF MYOSIN HEAVY-CHAIN BUT NOT ALPHA-ACTIN MESSENGER-RNA ISOFORMS DURING EARLY STAGES OF PRESSURE-OVERLOAD INDUCED RAT CARDIAC-HYPERTROPHY [J].

CHASSAGNE, C ;

WISNEWSKY, C ;

SCHWARTZ, K .

CIRCULATION RESEARCH, 1993, 72 (04) :857-864

[8] DEVELOPMENTAL DEFECTS OF THE EAR, CRANIAL NERVES AND HINDBRAIN RESULTING FROM TARGETED DISRUPTION OF THE MOUSE HOMEOBOX GENE HOX-1.6 [J].

CHISAKA, O ;

MUSCI, TS ;

CAPECCHI, MR .

NATURE, 1992, 355 (6360) :516-520

[9] REGIONALLY RESTRICTED DEVELOPMENTAL DEFECTS RESULTING FROM TARGETED DISRUPTION OF THE MOUSE HOMEOBOX GENE HOX-1.5 [J].

CHISAKA, O ;

CAPECCHI, MR .

NATURE, 1991, 350 (6318) :473-479

[10]

CSERJESI P, 1992, DEVELOPMENT, V115, P1087

← 1 2 3 4 5 →