4 NEW C-16 1,2-DIOXENE-POLYKETIDES FROM THE SPONGE PLAKORTIS-AFF-SIMPLEX

被引：26

作者：

RUDI, A

TALPIR, R

KASHMAN, Y

BENAYAHU, Y

SCHLEYER, M

机构：

[1] TEL AVIV UNIV,SCH CHEM,IL-69978 TEL AVIV,ISRAEL

[2] TEL AVIV UNIV,DEPT ZOOL,IL-69978 TEL AVIV,ISRAEL

[3] OCEANOG RES INST,DURBAN,SOUTH AFRICA

来源：

JOURNAL OF NATURAL PRODUCTS | 1993年 / 56卷 / 12期

关键词：

D O I：

10.1021/np50102a023

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new cyclic peroxide-containing polyketide C-16 acids 2 and 4 with their methylesters 3 and 5 have been isolated from the Indo-Pacific marine sponge Plakortis aff. simplex. Both 2 and 3 are proposed to contain a single 1,2-dioxene ring, while 4 and 5 incorporate two 1,2-dioxene rings. The structures were elucidated mainly through 1D and 2D nmr spectral analysis. The methyl esters 3 and 5 were found to be active against cultured P-388 murine leukemia cells.

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页码：2178 / 2182

页数：5

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