HETEROCHAIN POLYMERS BASED ON NATURAL AMINO-ACIDS - SYNTHESIS AND ENZYMATIC-HYDROLYSIS OF REGULAR POLY(ESTER AMIDE)S BASED ON BIS(L-PHENYLALANINE) ALPHA,OMEGA-ALKYLENE DIESTERS AND ADIPIC ACID

被引：53

作者：

ARABULI, N ^{[1
]}

TSITLANADZE, G ^{[1
]}

EDILASHVILI, L ^{[1
]}

KHARADZE, D ^{[1
]}

GOGUADZE, T ^{[1
]}

BERIDZE, V ^{[1
]}

GOMURASHVILI, Z ^{[1
]}

KATSARAVA, R ^{[1
]}

机构：

[1] GEORGIAN ACAD SCI, INST MOLEC BIOL & BIOL PHYS, 14 L GOTUA STR, 380060 TBILISI, GEORGIA

来源：

MACROMOLECULAR CHEMISTRY AND PHYSICS | 1994年 / 195卷 / 06期

关键词：

D O I：

10.1002/macp.1994.021950633

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Novel biodegradable regular poly(ester amide)s were synthesized by polycondensation of p-toluenesulfonic acid salts of bis(phenylalanine) alpha,omega-alkylene diesters (1) with bis(p-nitrophenyl) adipate under mild conditions in organic solvents in the presence of triethyl amine as acid acceptor. Enzymatic hydrolysis (alpha-chymotrypsinolysis) of the starting salts 1, the model bis(ester acetamide)s 2 and the obtained poly(ester amide)s 3 was investigated at 37-degrees-C and pH 8 using potentiometric titration. It was established that the hydrolysis rate increased with elongation of the alpha,omega-alkylene chain. A strong noncovalent immobilization of the enzyme on the polymeric surface was observed.

引用

页码：2279 / 2289

页数：11