SYNTHESIS OF METHYL [5,6,8,9,14,15-H-3(6)]-HEPOXILIN-B(3) AND ITS CONVERSION INTO METHYL [5,6,8,9,14,15-H-3(6)]-HEPOXILIN-A(3)

被引：16

作者：

DEMIN, PM

PIVNITSKY, KK

VASILJEVA, LL

PACEASCIAK, CR

机构：

[1] HOSP SICK CHILDREN,RES INST,TORONTO M5G 1X8,ONTARIO,CANADA

[2] RAMS,NATL ENDOCRINOL SCI CTR,INST EXPTL ENDOCRINOL,MOSCOW 115522,RUSSIA

[3] UNIV TORONTO,DEPT PHARMACOL,TORONTO M5S 1A8,ONTARIO,CANADA

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1994年 / 34卷 / 03期

关键词：

HEPOXILIN-A(3); HEPOXILIN-B(3); TRITIATION; MITSUNOBU INVERSION; ALLYLIC REARRANGEMENT;

D O I：

10.1002/jlcr.2580340304

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The selective tritiation of methyl 10(R/S)-hydroxy-11(R),12(S)-epoxyeicosa-5,8,14-triynoate into two C-10-epimeric [H-3(6)]-hepoxilins B3 methyl esters is described. These compounds are subsequently converted into two C-8-epimeric [H-3(6)]-hepoxilins A3 methyl esters by allylic rearrangement under Mitsunobu conditions via corresponding benzoates.

引用

收藏

页码：221 / 230

页数：10

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