METABOLISM AND MECHANISM OF ACTION OF 5-FLUOROURACIL

被引：333

作者：

PARKER, WB ^{[1
]}

CHENG, YC ^{[1
]}

机构：

[1] YALE UNIV,SCH MED,DEPT PHARMACOL,NEW HAVEN,CT 06510

来源：

PHARMACOLOGY & THERAPEUTICS | 1990年 / 48卷 / 03期

关键词：

D O I：

10.1016/0163-7258(90)90056-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This is a review on the mechanism of action of FUra. Three main areas are addressed: metabolism, RNA-directed actions of FUra, and DNA-directed actions of FUra. Key words for bibliographic purposes: metabolism, RNA, rRNA, mRNA, tRNA, DNA primase, DNA, thymidylate synthetase, uracil N-glycosylase, FUra, FUrd, FdUrd, FdUMP, RNA splicing, 5,10-methylene tetrahydrofolate, FUTP.

引用

页码：381 / 395

页数：15

共 135 条

[91] BIOCHEMICAL DETERMINANTS OF TUMOR SENSITIVITY TO 5-FLUOROURACIL - ULTRASENSITIVE METHODS FOR THE DETERMINATION OF 5-FLUORO-2'-DEOXYURIDYLATE, 2'-DEOXYURIDYLATE, AND THYMIDYLATE SYNTHETASE [J].