Total syntheses of polyamine amides PhTX-4.3.3 and PhTX-3.4.3: Reductive alkylation is a rapid, practical route to philanthotoxins

被引：21

作者：

Moya, E ^{[1
]}

Blagbrough, IS ^{[1
]}

机构：

[1] UNIV BATH, SCH PHARM & PHARMACOL, DEPT MED CHEM, BATH BA2 7AY, AVON, ENGLAND

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 51期

基金：

英国医学研究理事会; 英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1016/0040-4039(95)01996-U

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reductive alkylation allows a rapid and practical entry to the polyamine amide wasp toxin philanthotoxin-4.3.3. Philanthotoxin-3.4.3 has been prepared, in two steps, by the monoacylation of spermine. These polyamine amides are selective molecular pharmacological tools for cation channels gated by glutamic acid and acetylcholine, and may have potential as neuroprotective agents.

引用

页码：9401 / 9404

页数：4

共 18 条

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