Total synthesis of modified JS']JSTX toxins: Reductive alkylation is a practical route to hexahydropyrimidine polyamine amides

被引：16

作者：

Ashton, MR ^{[1
]}

Moya, E ^{[1
]}

Blagbrough, IS ^{[1
]}

机构：

[1] UNIV BATH, SCH PHARM & PHARMACOL, DEPT MED CHEM, BATH BA2 7AY, AVON, ENGLAND

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 51期

基金：

英国医学研究理事会; 英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1016/0040-4039(95)01995-T

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reductive alkylationis a practical route for a total synthesis of regioisomers of spider toxin JSTX-3, a polyamine amide which is a selective glutamate receptor antagonist and may have potential as a neuroprotective agent. The strategy is based upon a reductive alkylation step which enables one free amine to be generated regiospecifically in the new polyamine, ct the regiospecific incorporation of a hexahydropyrimidine moiety which conformationally restricts the polyamine amide backbone.

引用

页码：9397 / 9400

页数：4

共 24 条

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