THE 1ST POTENT INHIBITOR OF SQUALENE SYNTHASE - A PROFOUND CONTRIBUTION OF AN ETHER OXYGEN TO INHIBITOR ENZYME INTERACTION

被引：72

作者：

BILLER, SA

SOFIA, MJ

DELANGE, B

FORSTER, C

GORDON, EM

HARRITY, T

RICH, LC

CIOSEK, CP

机构：

[1] The Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1991年 / 113卷 / 22期

关键词：

D O I：

10.1021/ja00022a050

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[No abstract available]

引用

页码：8522 / 8524

页数：3

共 20 条

[1] EVALUATION OF INTRINSIC BINDING-ENERGY FROM A HYDROGEN-BONDING GROUP IN AN ENZYME-INHIBITOR [J].

BARTLETT, PA ;

MARLOWE, CK .

SCIENCE, 1987, 235 (4788) :569-571

[2]

BIILLER SA, 1990, DRUGS AFFECTING LIPI, V10, P213

[3] ISOPRENOID (PHOSPHINYLMETHYL)PHOSPHONATES AS INHIBITORS OF SQUALENE SYNTHETASE [J].

BILLER, SA ;

FORSTER, C ;

GORDON, EM ;

HARRITY, T ;

SCOTT, WA ;

CIOSEK, CP .

JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (10) :1869-1871

[4] THE SYNTHESIS OF ISOPRENOID (PHOSPHINYLMETHYL)PHOSPHONATES [J].

BILLER, SA ;

FORSTER, C .

TETRAHEDRON, 1990, 46 (19) :6645-6658

[5]

de Montellano P R, 1977, J Med Chem, V20, P243

[6]

HANDLER B, 1991, 201ST NAT M AM CHEM

[7] INTRINSIC HYDROPHILIC CHARACTER OF ORGANIC COMPOUNDS - CORRELATIONS IN TERMS OF STRUCTURAL CONTRIBUTIONS [J].

HINE, J ;

MOOKERJEE, PK .

JOURNAL OF ORGANIC CHEMISTRY, 1975, 40 (03) :292-298

[8] MOLECULAR-CLONING AND CHARACTERIZATION OF THE YEAST GENE FOR SQUALENE SYNTHETASE [J].

JENNINGS, SM ;

TSAY, YH ;

FISCH, TM ;

ROBINSON, GW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (14) :6038-6042

[9] CONTRIBUTION OF A SINGLE HYDROXYL GROUP TO TRANSITION-STATE DISCRIMINATION BY ADENOSINE-DEAMINASE - EVIDENCE FOR AN ENTROPY TRAP MECHANISM [J].

KATI, WM ;

WOLFENDEN, R .

BIOCHEMISTRY, 1989, 28 (19) :7919-7927

[10]

KOYAMA T, 1980, BIOCHIM BIOPHYS ACTA, V617, P218

← 1 2 →