THE 1ST POTENT INHIBITOR OF SQUALENE SYNTHASE - A PROFOUND CONTRIBUTION OF AN ETHER OXYGEN TO INHIBITOR ENZYME INTERACTION

被引：72

作者：

BILLER, SA

SOFIA, MJ

DELANGE, B

FORSTER, C

GORDON, EM

HARRITY, T

RICH, LC

CIOSEK, CP

机构：

[1] The Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1991年 / 113卷 / 22期

关键词：

D O I：

10.1021/ja00022a050

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[No abstract available]

引用

页码：8522 / 8524

页数：3

共 20 条

[11] FARNESYLPYROPHOSPHATE SYNTHETASE - EVIDENCE FOR A RIGID GERANYL CATION-PYROPHOSPHATE ANION PAIR [J].

MASH, EA ;

GURRIA, GM ;

POULTER, CD .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, 103 (13) :3927-3929

[12] NOVEL PHOSPHONYLPHOSPHINYL (P-C-P-C-) ANALOGS OF BIOCHEMICALLY INTERESTING DIPHOSPHATES - SYNTHESES AND PROPERTIES OF P-C-P-C- ANALOGS OF ISOPENTENYL DIPHOSPHATE AND DIMETHYLALLYL DIPHOSPHATE [J].

MCCLARD, RW ;

FUJITA, TS ;

STREMLER, KE ;

POULTER, CD .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (18) :5544-5545

[13] DIFFERENTIAL BINDING-ENERGY - A DETAILED EVALUATION OF THE INFLUENCE OF HYDROGEN-BONDING AND HYDROPHOBIC GROUPS ON THE INHIBITION OF THERMOLYSIN BY PHOSPHORUS-CONTAINING INHIBITORS [J].

MORGAN, BP ;

SCHOLTZ, JM ;

BALLINGER, MD ;

ZIPKIN, ID ;

BARTLETT, PA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (01) :297-307

[14] BIOSYNTHESIS OF NON-HEAD-TO-TAIL TERPENES - FORMATION OF 1'-1 AND 1'-3 LINKAGES [J].

POULTER, CD .

ACCOUNTS OF CHEMICAL RESEARCH, 1990, 23 (03) :70-77

[15] FARNESYLPYROPHOSPHATE SYNTHETASE - A STEPWISE MECHANISM FOR THE 1'-4 CONDENSATION REACTION [J].

POULTER, CD ;

WIGGINS, PL ;

LE, AT .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, 103 (13) :3926-3927

[16]

POULTER CD, 1981, BIOSYNTHESIS ISOPREN, V1, pCH8

[17]

POULTER CD, 1981, BIOSYNTHESIS ISOPREN, V1, pCH4

[18]

POULTER CD, 1981, PR NAUK I CHEM ORG F, V22, P149

[19] THE MECHANISM OF THE CONDENSATION-REACTIONS OF CHOLESTEROL-BIOSYNTHESIS [J].

RILLING, HC .

BIOCHEMICAL SOCIETY TRANSACTIONS, 1985, 13 (06) :997-1003

[20] PURIFICATION TO HOMOGENEITY AND SOME PROPERTIES OF SQUALENE SYNTHETASE [J].

SASIAK, K ;

RILLING, HC .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1988, 260 (02) :622-627

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