EFFECTS OF RICE BRAN HEMICELLULOSE ON 1,2-DIMETHYLHYDRAZINE-INDUCED INTESTINAL CARCINOGENESIS IN FISCHER 344 RATS

被引:24
作者
AOE, S [1 ]
ODA, T [1 ]
TOJIMA, T [1 ]
TANAKA, M [1 ]
TATSUMI, K [1 ]
MIZUTANI, T [1 ]
机构
[1] INST PHYS & CHEM RES,LAB ANIM RES CTR,WAKO,SAITAMA 35001,JAPAN
来源
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 1993年 / 20卷 / 01期
关键词
D O I
10.1080/01635589309514269
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The effect of rice bran hemicellulose (RBH) on 1,2-dimethylhydrazine- (DMH) induced intestinal carcinogenesis was studied in male Fischer 344 rats. Rats were fed a basal control diet or a diet containing 2% or 4% PBH at five weeks of age. At 6 weeks of age, all animals were given an intraperitoneal injection of DMH (20 mg/kg body wt) at weekly intervals for 20 weeks and autopsied 7 weeks after the last injection. The incidence of DMH-induced colon tumors was significantly lower in rats fed the 4% RBH diet than in rats fed the basal control diet (p < 0.05). The number of colon tumors per rat was also significantly lower in rats fed the 4% RBH diet than in rats fed the basal control diet (p < 0.05). The present study suggested that the water-soluble RBH played a preventive role in DMH-induced large bowel carcinogenesis in Fischer 344 rats.
引用
收藏
页码:41 / 49
页数:9
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