EFFECTS OF RICE BRAN HEMICELLULOSE ON 1,2-DIMETHYLHYDRAZINE-INDUCED INTESTINAL CARCINOGENESIS IN FISCHER 344 RATS

被引：24

作者：

AOE, S ^{[1
]}

ODA, T ^{[1
]}

TOJIMA, T ^{[1
]}

TANAKA, M ^{[1
]}

TATSUMI, K ^{[1
]}

MIZUTANI, T ^{[1
]}

机构：

[1] INST PHYS & CHEM RES,LAB ANIM RES CTR,WAKO,SAITAMA 35001,JAPAN

来源：

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 1993年 / 20卷 / 01期

关键词：

D O I：

10.1080/01635589309514269

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The effect of rice bran hemicellulose (RBH) on 1,2-dimethylhydrazine- (DMH) induced intestinal carcinogenesis was studied in male Fischer 344 rats. Rats were fed a basal control diet or a diet containing 2% or 4% PBH at five weeks of age. At 6 weeks of age, all animals were given an intraperitoneal injection of DMH (20 mg/kg body wt) at weekly intervals for 20 weeks and autopsied 7 weeks after the last injection. The incidence of DMH-induced colon tumors was significantly lower in rats fed the 4% RBH diet than in rats fed the basal control diet (p < 0.05). The number of colon tumors per rat was also significantly lower in rats fed the 4% RBH diet than in rats fed the basal control diet (p < 0.05). The present study suggested that the water-soluble RBH played a preventive role in DMH-induced large bowel carcinogenesis in Fischer 344 rats.

引用

页码：41 / 49

页数：9

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