PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS - CLINICAL COURSE AND RESPONSE TO THERAPY

被引：227

作者：

KORBET, SM ^{[1
]}

SCHWARTZ, MM ^{[1
]}

LEWIS, EJ ^{[1
]}

机构：

[1] RUSH PRESBYTERIAN ST LUKES MED CTR,DEPT PATHOL,NEPHROL SECT,CHICAGO,IL 60612

来源：

AMERICAN JOURNAL OF KIDNEY DISEASES | 1994年 / 23卷 / 06期

关键词：

PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS; FOCAL SEGMENTAL GLOMERULOSCLEROSIS; NEPHROTIC SYNDROME; TREATMENT;

D O I：

10.1016/S0272-6386(12)80128-4

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Primary focal segmental glomerulosclerosis (FSGS) is a lesion associated with a poor prognosis and results in end-stage renal disease after 5 to 10 years. Based on past experience, many nephrologists have considered primary FSGS a lesion that is steroid resistant and therefore are reluctant to offer steroids as treatment. Recent data, however, have demonstrated that patients with primary FSGS have a response to steroid therapy that is considerably better than had been described. Thus, it may be that nephrologists have been more “steroid reluctant” than the lesion is steroid resistant. To better understand this issue we review the clinical course and response to therapy in patients with nrimarv FSGS. © 1994, National Kidney Foundation. All rights reserved. All rights reserved.

引用

页码：773 / 783

页数：11

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