INFLUENCE OF AN ADHESIVE CELL-SURFACE PROTEIN ON CHONDROGENIC EXPRESSION INVITRO

被引：132

作者：

PENNYPACKER, JP

HASSELL, JR

YAMADA, KM

PRATT, RM

机构：

[1] NEI,CLIN BRANCH,BETHESDA,MD 20014

[2] NCI,MOLEC BIOL LAB,BETHESDA,MD 20014

来源：

EXPERIMENTAL CELL RESEARCH | 1979年 / 121卷 / 02期

关键词：

D O I：

10.1016/0014-4827(79)90022-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Fibronectin is a major glycoprotein associated with fibroblasts and other cells of mesenchymal origin. However, when mesenchyme differentiates into cartilage, fibronectin is no longer synthesized. The significance of the change in fibronectin was further evaluated by culturing chondrocytes in the presence of exogenous fibronectin. Treatment with fibronectin caused the chondrocytes to assume a fibroblastic morphology and also enhanced other fibroblastic properties. These results suggest that decreased fibronectin levels may be required for chondrogenesis to occur normally. © 1979.

引用

页码：411 / 415

页数：5

共 21 条

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