ABSENCE OF EXPRESSION OF INTERLEUKIN-6 (IL-6) MESSENGER-RNA IN REGENERATING RAT-LIVER

被引：13

作者：

SCOTTE, M ^{[1
]}

DAVEAU, M ^{[1
]}

HIRON, M ^{[1
]}

TENIERE, P ^{[1
]}

LEBRETON, JP ^{[1
]}

机构：

[1] INSERM,UNITE 78,BP 73,F-76233 BOIS GUILLAUME,FRANCE

来源：

FEBS LETTERS | 1993年 / 315卷 / 02期

关键词：

INTERLEUKIN-6; HEPATIC REGENERATION; RAT;

D O I：

10.1016/0014-5793(93)81154-R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The serum level of IL-6 and expression of IL-6 mRNA in hepatocytes from regenerating liver were investigated in the rat. The IL-6 level in the serum was not significantly different from that of a control group of rats submitted to an acute experimental inflammation. IL-6 mRNA expression did not occur in the liver of hepatectomized rats as judged from Northern blotting experiments using an IL-6 riboprobe. These results suggest that if IL-6 is implicated in hepatic regeneration, this cytokine is not produced by the regenerating liver and must be delivered exogenously to the liver to modulate hepatic regeneration.

引用

页码：159 / 162

页数：4

共 26 条

[1] ULTRASTRUCTURAL-STUDY OF HEPATIC REGENERATION FOLLOWING ONE-LOBE, 2-LOBE, AND SUBTOTAL HEPATECTOMY IN THE RAT [J].