PARALLEL REGULATION OF PARENTALLY IMPRINTED H19 AND INSULIN-LIKE GROWTH FACTOR-II GENES IN CULTURED HUMAN FETAL ADRENAL-CELLS

被引:43
作者
VOUTILAINEN, R
ILVESMAKI, V
ARIEL, I
RACHMILEWITZ, J
DEGROOT, N
HOCHBERG, A
机构
[1] UNIV HELSINKI, DEPT PEDIAT, HELSINKI, FINLAND
[2] HADASSAH UNIV HOSP, DEPT PATHOL, IL-91120 JERUSALEM, ISRAEL
[3] HEBREW UNIV JERUSALEM, SILBERMAN INST LIFE SCI, DEPT BIOL CHEM, JERUSALEM, ISRAEL
关键词
D O I
10.1210/en.134.5.2051
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Adjacent, parentally imprinted, insulin-like growth factor-II (IGF-II) and H19 genes are highly expressed during embryogenesis and are important for fetal growth. Human fetal adrenals express abundantly both IGF-II and H19 genes. To clarify the significance and regulation of the H19 gene, we studied its expression in fetal adrenals. In situ hybridization experiments showed H19 RNA expression throughout the fetal adrenal cortex, with slightly higher expression in the outer definitive (adult) than in the inner fetal zone. In primary cultures of fetal adrenal cells, ACTH and other activators of the protein kinase-il signal transduction pathway increased both H19 and IGF-II RNA accumulation 1.7- to 10-fold. Staurosporine, a protein kinase-C inhibitor, increased H19 and IGF-II RNA to the same extent as did ACTH. The protein kinase-C activator 12-O-tetradecanoyl phorbol-13-acetate and cytokines, tumor necrosis factor-alpha and interferon-gamma, inhibited H19 and IGF-II RNA accumulation. Transforming growth factor-beta 1 caused a decrease in levels of H19 and IGF-II RNA, whereas the IGFs caused a slight increase. Our data show parallel multifactorial regulation of H19 and IGF-II RNAs in human fetal adrenal cells. This suggests common regulatory mechanisms for these adjacent genes.
引用
收藏
页码:2051 / 2056
页数:6
相关论文
共 52 条
[31]   PROTEIN KINASE-C IS CRUCIAL IN SIGNAL TRANSDUCTION DURING IFN-GAMMA INDUCTION IN ENDOTHELIAL-CELLS [J].
MATTILA, P ;
HAYRY, P ;
RENKONEN, R .
FEBS LETTERS, 1989, 250 (02) :362-366
[32]   DUAL REGULATION OF 3-BETA-HYDROXYSTEROID DEHYDROGENASE, 17-ALPHA-HYDROXYLASE, AND DEHYDROEPIANDROSTERONE SULFOTRANSFERASE BY ADENOSINE-3',5'-MONOPHOSPHATE AND ACTIVATORS OF PROTEIN KINASE-C IN CULTURED HUMAN ADRENOCORTICAL-CELLS [J].
MCALLISTER, JM ;
HORNSBY, PJ .
ENDOCRINOLOGY, 1988, 122 (05) :2012-2018
[33]   MITOGENIC ACTION, REGULATION, AND LOCALIZATION OF INSULIN-LIKE GROWTH-FACTORS IN THE HUMAN FETAL ADRENAL-GLAND [J].
MESIANO, S ;
MELLON, SH ;
JAFFE, RB .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1993, 76 (04) :968-976
[35]   RELAXATION OF INSULIN-LIKE GROWTH FACTOR-II GENE IMPRINTING IMPLICATED IN WILMS-TUMOR [J].
OGAWA, O ;
ECCLES, MR ;
SZETO, J ;
MCNOE, LA ;
YUN, K ;
MAW, MA ;
SMITH, PJ ;
REEVE, AE .
NATURE, 1993, 362 (6422) :749-751
[36]   REGULATION OF THE PRIMATE FETAL ADRENAL-CORTEX [J].
PEPE, GJ ;
ALBRECHT, ED .
ENDOCRINE REVIEWS, 1990, 11 (01) :151-176
[37]  
POIRIER F, 1991, DEVELOPMENT, V113, P1105
[38]   TRANSCRIPTION OF THE H19 GENE IN DIFFERENTIATING CYTOTROPHOBLASTS FROM HUMAN PLACENTA [J].
RACHMILEWITZ, J ;
GILEADI, O ;
ELDARGEVA, T ;
SCHNEIDER, T ;
DEGROOT, N ;
HOCHBERG, A .
MOLECULAR REPRODUCTION AND DEVELOPMENT, 1992, 32 (03) :196-202
[39]   PARENTAL IMPRINTING OF THE HUMAN H19 GENE [J].
RACHMILEWITZ, J ;
GOSHEN, R ;
ARIEL, I ;
SCHNEIDER, T ;
DEGROOT, N ;
HOCHBERG, A .
FEBS LETTERS, 1992, 309 (01) :25-28
[40]   RELAXATION OF IMPRINTED GENES IN HUMAN CANCER [J].
RAINIER, S ;
JOHNSON, LA ;
DOBRY, CJ ;
PING, AJ ;
GRUNDY, PE ;
FEINBERG, AP .
NATURE, 1993, 362 (6422) :747-749