APOLIPOPROTEIN-E INHIBITION OF PROLIFERATION OF MITOGEN-ACTIVATED T-LYMPHOCYTES - PRODUCTION OF INTERLEUKIN-2 WITH REDUCED BIOLOGICAL-ACTIVITY

被引:113
作者
KELLY, ME
CLAY, MA
MISTRY, MJ
HSIEHLI, HM
HARMONY, JAK
机构
[1] UNIV CINCINNATI,COLL MED,DEPT PHARMACOL & CELL BIOPHYS,CINCINNATI,OH 45267
[2] UNIV CINCINNATI,COLL MED,DEV BIOL PROGRAM,CINCINNATI,OH 45267
关键词
D O I
10.1006/cimm.1994.1302
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Apolipoprotein E (apoE), but not apoAI or apoCIII, suppresses mitogen-activated T lymphocyte proliferation, independent of the type of activation signal. Both CD4 and CD8 T cells are inhibited. ApoE inhibits T cell proliferation, in part, by reducing the production of bioactive interleukin 2 (IL2). IL2 activity is reduced by similar to 50-65% in cultures of mitogen-stimulated T cells when apoE is present. ApoE does not significantly alter levels of IL2 mRNA or the mass of secreted IL2 protein, quantitated by enzyme immunoassay. Reduced IL2 activity was not a consequence of induction of IL2 inhibitors in response to apoE or effects of apoE on the bioassay. These results suggest that apoE antagonizes post-translational events in mitogen-activated T lymphocytes that are required for the secretion of a bioactive IL2 protein. (C) 1994 Academic Press. Inc.
引用
收藏
页码:124 / 139
页数:16
相关论文
共 57 条
  • [1] SIGNAL TRANSDUCTION THROUGH THE T-CELL ANTIGEN RECEPTOR
    ABRAHAM, RT
    KARNITZ, LM
    SECRIST, JP
    LEIBSON, PJ
    [J]. TRENDS IN BIOCHEMICAL SCIENCES, 1992, 17 (10) : 434 - 438
  • [2] AKESON AL, 1984, J LIPID RES, V25, P1195
  • [3] ANDEREGG RJ, 1988, J BIOL CHEM, V263, P18236
  • [4] AVILA EM, 1982, J BIOL CHEM, V257, P5900
  • [5] HEMATOPOIETIC RECEPTORS AND HELICAL CYTOKINES
    BAZAN, JF
    [J]. IMMUNOLOGY TODAY, 1990, 11 (10): : 350 - 354
  • [6] BOCKENSTEDT LK, 1988, J IMMUNOL, V141, P1904
  • [7] BOURNPAS DT, 1991, J CLIN INVEST, V87, P1739
  • [8] CARDIN AD, 1984, METHOD PHARMACOL, P141
  • [9] SINGLE-STEP METHOD OF RNA ISOLATION BY ACID GUANIDINIUM THIOCYANATE PHENOL CHLOROFORM EXTRACTION
    CHOMCZYNSKI, P
    SACCHI, N
    [J]. ANALYTICAL BIOCHEMISTRY, 1987, 162 (01) : 156 - 159
  • [10] CIARDELLI TL, 1988, INTERLEUKIN 2, P67