SEPARATION OF ISOMERIC COMPOUNDS BY REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY USING AG+ COMPLEXATION - APPLICATION TO CIS-TRANS FATTY-ACID METHYL-ESTERS AND RETINOIC ACID PHOTOISOMERS

被引：10

作者：

BAILLET, A

CORBEAU, L

RAFIDISON, P

FERRIER, D

机构：

[1] Centre d'Études Pharmaceutiques, Laboratoire de Chimie Analytique, F-92296 Chatenay-Malabry Cedex, Rue J.B. Clément

来源：

JOURNAL OF CHROMATOGRAPHY | 1993年 / 634卷 / 02期

关键词：

D O I：

10.1016/0021-9673(93)83011-G

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The improvement of the chromatographic efficiency using Ag+ complexing reversed-phase liquid chromatography for the analysis of geometric isomers was studied. The influence of the nature and concentration of silver salts on pi-complex formation was investigated with two types of sample, fatty acid methyl esters and trans-retinoic acid photoisomers. First, the separations of cis-trans-linoleic acids and cis-trans-oleic acids were confirmed. Second, the pi-complexation was shown to occur with more complex chemical structures such as trans-retinoic acid and its photoisomers. The chromatographic separation of seven geometric isomers of trans-retinoic acid was then carried out with good efficiency in half the time required in previous work.

引用

页码：251 / 256

页数：6

共 16 条

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