DEVELOPMENTAL TOXICITY OF FUMONISIN IN SYRIAN-HAMSTERS

被引：30

作者：

FLOSS, JL

CASTEEL, SW

JOHNSON, GC

ROTTINGHAUS, GE

KRAUSE, GF

机构：

[1] UNIV MISSOURI, COLL VET MED, VET MED DIAGNOST LAB, COLUMBIA, MO USA

[2] UNIV MISSOURI, AGR EXPT STN, COLUMBIA, MO USA

来源：

MYCOPATHOLOGIA | 1994年 / 128卷 / 01期

关键词：

DEVELOPMENTAL TOXICITY; FETAL TOXICITY; FUMONISIN; FUSARIUM MONILIFORME; HAMSTER;

D O I：

10.1007/BF01104276

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The effects of fumonisin on development of Syrian hamster fetuses were studied using fumonisin B-1 and B-2 extracted from Fusarium moniliforme corn-culture and purified fumonisin B-1. A significant increase in litters with fetal deaths occurred with the high doses of purified (18 mg FB1/kg) and culture-extracted (18 mg FB1 plus 4.5 mg FB2) fumonisin. It is concluded that prenatal exposure to fumonisin on days 8 and 9 of gestation is detrimental to fetal hamster survivability but does not induce clinical maternal intoxication at these doses. Equivalent doses of fumonisin B-1, whether from culture-extract or pure solution produced similar results.

引用

页码：33 / 38

页数：6