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MOLECULAR AND BIOLOGICAL CHARACTERIZATION OF A HERPES-SIMPLEX VIRUS TYPE-1 (HSV-1) NEUROINVASIVENESS GENE
被引:77
作者
:
IZUMI, KM
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF LOS ANGELES,SCH MED,DEPT MICROBIOL & IMMUNOL,LOS ANGELES,CA 90024
IZUMI, KM
STEVENS, JG
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF LOS ANGELES,SCH MED,DEPT MICROBIOL & IMMUNOL,LOS ANGELES,CA 90024
STEVENS, JG
机构
:
[1]
UNIV CALIF LOS ANGELES,SCH MED,DEPT MICROBIOL & IMMUNOL,LOS ANGELES,CA 90024
[2]
UNIV CALIF LOS ANGELES,SCH MED,REED NEUROL RES CTR,LOS ANGELES,CA 90024
来源
:
JOURNAL OF EXPERIMENTAL MEDICINE
|
1990年
/ 172卷
/ 02期
关键词
:
D O I
:
10.1084/jem.172.2.487
中图分类号
:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号
:
100102 ;
摘要
:
Pathogenetic studies of herpes simplex virus type 1 (HSV1) strains ANG and its mouse brainpassaged descendant ANG path revealed no difference in neurovirulence but a significant difference in neuroinvasiveness. Thus, both viruses induced a fatal encephalitis in mice after direct injection into the brain, but only ANG path induced lethal neurologic disease after inoculation on rear footpads. The difference in neuroinvasiveness is not related to the capacity to replicate in mouse neural tissues or mouse cells in general, but is specifically related to virus entry into the peripheral nervous system in the footpad. Marker rescue experiments in which ANG path genes were used to confer neuroinvasiveness on ANG indicated that the gene that codes for glycoprotein D (gD) is responsible for the phenotypic difference. Analyses of the gD genes by dideoxy-sequencing techniques identified a base difference in the coding sequences and predicted that the ANG gD gene codes for alanine (GCC codon) at amino acid position 84 in the open reading frame and the ANG path gD gene codes for glycine (GGC codon) at this site. Using these data, an oligonucleotide probe predicted to be specific for the ANG path gD gene was prepared, and in Southern blot analyses, this probe revealed that neuroinvasiveness-rescued agents had incorporated the base change seen in the ANG path gD gene. We conclude that HSV1 glycoprotein D functions to effect neuroinvasiveness and we discuss potential mechanisms that may be involved. © 1990, Rockefeller University Press., All rights reserved.
引用
收藏
页码:487 / 496
页数:10
相关论文
共 31 条
[11]
HERPES-SIMPLEX VIRUSES LACKING GLYCOPROTEIN-D ARE UNABLE TO INHIBIT VIRUS PENETRATION - QUANTITATIVE EVIDENCE FOR VIRUS-SPECIFIC CELL-SURFACE RECEPTORS
JOHNSON, DC
论文数:
0
引用数:
0
h-index:
0
JOHNSON, DC
LIGAS, MW
论文数:
0
引用数:
0
h-index:
0
LIGAS, MW
[J].
JOURNAL OF VIROLOGY,
1988,
62
(12)
: 4605
-
4612
[12]
HERPES-SIMPLEX VIRUS IMMUNOGLOBULIN-G FC-RECEPTOR ACTIVITY DEPENDS ON A COMPLEX OF 2 VIRAL GLYCOPROTEIN-GE AND GLYCOPROTEIN-GI
JOHNSON, DC
论文数:
0
引用数:
0
h-index:
0
机构:
INST VIROL, MRC, VIROL UNIT, GLASGOW G11 5JR, SCOTLAND
INST VIROL, MRC, VIROL UNIT, GLASGOW G11 5JR, SCOTLAND
JOHNSON, DC
FRAME, MC
论文数:
0
引用数:
0
h-index:
0
机构:
INST VIROL, MRC, VIROL UNIT, GLASGOW G11 5JR, SCOTLAND
INST VIROL, MRC, VIROL UNIT, GLASGOW G11 5JR, SCOTLAND
FRAME, MC
LIGAS, MW
论文数:
0
引用数:
0
h-index:
0
机构:
INST VIROL, MRC, VIROL UNIT, GLASGOW G11 5JR, SCOTLAND
INST VIROL, MRC, VIROL UNIT, GLASGOW G11 5JR, SCOTLAND
LIGAS, MW
CROSS, AM
论文数:
0
引用数:
0
h-index:
0
机构:
INST VIROL, MRC, VIROL UNIT, GLASGOW G11 5JR, SCOTLAND
INST VIROL, MRC, VIROL UNIT, GLASGOW G11 5JR, SCOTLAND
CROSS, AM
STOW, ND
论文数:
0
引用数:
0
h-index:
0
机构:
INST VIROL, MRC, VIROL UNIT, GLASGOW G11 5JR, SCOTLAND
INST VIROL, MRC, VIROL UNIT, GLASGOW G11 5JR, SCOTLAND
STOW, ND
[J].
JOURNAL OF VIROLOGY,
1988,
62
(04)
: 1347
-
1354
[13]
GENETIC-VARIABILITY OF HERPES-SIMPLEX VIRUS - DEVELOPMENT OF A PATHOGENIC VARIANT DURING PASSAGING OF A NON-PATHOGENIC HERPES-SIMPLEX VIRUS TYPE-1 VIRUS-STRAIN IN MOUSE-BRAIN
KAERNER, HC
论文数:
0
引用数:
0
h-index:
0
KAERNER, HC
SCHRODER, CH
论文数:
0
引用数:
0
h-index:
0
SCHRODER, CH
OTTHARTMANN, A
论文数:
0
引用数:
0
h-index:
0
OTTHARTMANN, A
KUMEL, G
论文数:
0
引用数:
0
h-index:
0
KUMEL, G
KIRCHNER, H
论文数:
0
引用数:
0
h-index:
0
KIRCHNER, H
[J].
JOURNAL OF VIROLOGY,
1983,
46
(01)
: 83
-
93
[14]
EXPERIMENTAL-INFECTION OF INBRED MICE WITH HERPES-SIMPLEX VIRUS .5. INVESTIGATIONS WITH A VIRUS-STRAIN NON-LETHAL AFTER PERIPHERAL INFECTION
KUMEL, G
论文数:
0
引用数:
0
h-index:
0
KUMEL, G
KIRCHNER, H
论文数:
0
引用数:
0
h-index:
0
KIRCHNER, H
ZAWATZKY, R
论文数:
0
引用数:
0
h-index:
0
ZAWATZKY, R
ENGLER, H
论文数:
0
引用数:
0
h-index:
0
ENGLER, H
SCHRODER, CH
论文数:
0
引用数:
0
h-index:
0
SCHRODER, CH
KAERNER, HC
论文数:
0
引用数:
0
h-index:
0
KAERNER, HC
[J].
JOURNAL OF GENERAL VIROLOGY,
1982,
63
(DEC)
: 315
-
323
[15]
Maniatis T., 1982, MOL CLONING
[16]
MECHANISMS OF ANTIVIRAL IMMUNITY INDUCED BY A VACCINIA VIRUS RECOMBINANT EXPRESSING HERPES-SIMPLEX VIRUS TYPE-1 GLYCOPROTEIN-D - CYTOTOXIC T-CELLS
MARTIN, S
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV TENNESSEE,COLL VET MED,DEPT MICROBIOL,KNOXVILLE,TN 37996
MARTIN, S
MOSS, B
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV TENNESSEE,COLL VET MED,DEPT MICROBIOL,KNOXVILLE,TN 37996
MOSS, B
BERMAN, PW
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV TENNESSEE,COLL VET MED,DEPT MICROBIOL,KNOXVILLE,TN 37996
BERMAN, PW
LASKEY, LA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV TENNESSEE,COLL VET MED,DEPT MICROBIOL,KNOXVILLE,TN 37996
LASKEY, LA
ROUSE, BT
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV TENNESSEE,COLL VET MED,DEPT MICROBIOL,KNOXVILLE,TN 37996
ROUSE, BT
[J].
JOURNAL OF VIROLOGY,
1987,
61
(03)
: 726
-
734
[17]
SYNTHESIS AND PROCESSING OF GLYCOPROTEIN-D OF HERPES-SIMPLEX VIRUS TYPE-1 AND TYPE-2 IN AN INVITRO SYSTEM
MATTHEWS, JT
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV PENN, SCH DENT MED, CTR ORAL HLTH RES, PHILADELPHIA, PA 19104 USA
MATTHEWS, JT
COHEN, GH
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV PENN, SCH DENT MED, CTR ORAL HLTH RES, PHILADELPHIA, PA 19104 USA
COHEN, GH
EISENBERG, RJ
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV PENN, SCH DENT MED, CTR ORAL HLTH RES, PHILADELPHIA, PA 19104 USA
EISENBERG, RJ
[J].
JOURNAL OF VIROLOGY,
1983,
48
(02)
: 521
-
533
[18]
SEQUENCE DETERMINATION AND GENETIC CONTENT OF THE SHORT UNIQUE REGION IN THE GENOME OF HERPES-SIMPLEX VIRUS TYPE-1
MCGEOCH, DJ
论文数:
0
引用数:
0
h-index:
0
MCGEOCH, DJ
DOLAN, A
论文数:
0
引用数:
0
h-index:
0
DOLAN, A
DONALD, S
论文数:
0
引用数:
0
h-index:
0
DONALD, S
RIXON, FJ
论文数:
0
引用数:
0
h-index:
0
RIXON, FJ
[J].
JOURNAL OF MOLECULAR BIOLOGY,
1985,
181
(01)
: 1
-
13
[19]
THE COMPLETE DNA-SEQUENCE OF THE LONG UNIQUE REGION IN THE GENOME OF HERPES-SIMPLEX VIRUS TYPE-1
MCGEOCH, DJ
论文数:
0
引用数:
0
h-index:
0
MCGEOCH, DJ
DALRYMPLE, MA
论文数:
0
引用数:
0
h-index:
0
DALRYMPLE, MA
DAVISON, AJ
论文数:
0
引用数:
0
h-index:
0
DAVISON, AJ
DOLAN, A
论文数:
0
引用数:
0
h-index:
0
DOLAN, A
FRAME, MC
论文数:
0
引用数:
0
h-index:
0
FRAME, MC
MCNAB, D
论文数:
0
引用数:
0
h-index:
0
MCNAB, D
PERRY, LJ
论文数:
0
引用数:
0
h-index:
0
PERRY, LJ
SCOTT, JE
论文数:
0
引用数:
0
h-index:
0
SCOTT, JE
TAYLOR, P
论文数:
0
引用数:
0
h-index:
0
TAYLOR, P
[J].
JOURNAL OF GENERAL VIROLOGY,
1988,
69
: 1531
-
1574
[20]
MIMS CA, 1984, VIRAL PATHOGENESIS I, P158
←
1
2
3
4
→
共 31 条
[11]
HERPES-SIMPLEX VIRUSES LACKING GLYCOPROTEIN-D ARE UNABLE TO INHIBIT VIRUS PENETRATION - QUANTITATIVE EVIDENCE FOR VIRUS-SPECIFIC CELL-SURFACE RECEPTORS
JOHNSON, DC
论文数:
0
引用数:
0
h-index:
0
JOHNSON, DC
LIGAS, MW
论文数:
0
引用数:
0
h-index:
0
LIGAS, MW
[J].
JOURNAL OF VIROLOGY,
1988,
62
(12)
: 4605
-
4612
[12]
HERPES-SIMPLEX VIRUS IMMUNOGLOBULIN-G FC-RECEPTOR ACTIVITY DEPENDS ON A COMPLEX OF 2 VIRAL GLYCOPROTEIN-GE AND GLYCOPROTEIN-GI
JOHNSON, DC
论文数:
0
引用数:
0
h-index:
0
机构:
INST VIROL, MRC, VIROL UNIT, GLASGOW G11 5JR, SCOTLAND
INST VIROL, MRC, VIROL UNIT, GLASGOW G11 5JR, SCOTLAND
JOHNSON, DC
FRAME, MC
论文数:
0
引用数:
0
h-index:
0
机构:
INST VIROL, MRC, VIROL UNIT, GLASGOW G11 5JR, SCOTLAND
INST VIROL, MRC, VIROL UNIT, GLASGOW G11 5JR, SCOTLAND
FRAME, MC
LIGAS, MW
论文数:
0
引用数:
0
h-index:
0
机构:
INST VIROL, MRC, VIROL UNIT, GLASGOW G11 5JR, SCOTLAND
INST VIROL, MRC, VIROL UNIT, GLASGOW G11 5JR, SCOTLAND
LIGAS, MW
CROSS, AM
论文数:
0
引用数:
0
h-index:
0
机构:
INST VIROL, MRC, VIROL UNIT, GLASGOW G11 5JR, SCOTLAND
INST VIROL, MRC, VIROL UNIT, GLASGOW G11 5JR, SCOTLAND
CROSS, AM
STOW, ND
论文数:
0
引用数:
0
h-index:
0
机构:
INST VIROL, MRC, VIROL UNIT, GLASGOW G11 5JR, SCOTLAND
INST VIROL, MRC, VIROL UNIT, GLASGOW G11 5JR, SCOTLAND
STOW, ND
[J].
JOURNAL OF VIROLOGY,
1988,
62
(04)
: 1347
-
1354
[13]
GENETIC-VARIABILITY OF HERPES-SIMPLEX VIRUS - DEVELOPMENT OF A PATHOGENIC VARIANT DURING PASSAGING OF A NON-PATHOGENIC HERPES-SIMPLEX VIRUS TYPE-1 VIRUS-STRAIN IN MOUSE-BRAIN
KAERNER, HC
论文数:
0
引用数:
0
h-index:
0
KAERNER, HC
SCHRODER, CH
论文数:
0
引用数:
0
h-index:
0
SCHRODER, CH
OTTHARTMANN, A
论文数:
0
引用数:
0
h-index:
0
OTTHARTMANN, A
KUMEL, G
论文数:
0
引用数:
0
h-index:
0
KUMEL, G
KIRCHNER, H
论文数:
0
引用数:
0
h-index:
0
KIRCHNER, H
[J].
JOURNAL OF VIROLOGY,
1983,
46
(01)
: 83
-
93
[14]
EXPERIMENTAL-INFECTION OF INBRED MICE WITH HERPES-SIMPLEX VIRUS .5. INVESTIGATIONS WITH A VIRUS-STRAIN NON-LETHAL AFTER PERIPHERAL INFECTION
KUMEL, G
论文数:
0
引用数:
0
h-index:
0
KUMEL, G
KIRCHNER, H
论文数:
0
引用数:
0
h-index:
0
KIRCHNER, H
ZAWATZKY, R
论文数:
0
引用数:
0
h-index:
0
ZAWATZKY, R
ENGLER, H
论文数:
0
引用数:
0
h-index:
0
ENGLER, H
SCHRODER, CH
论文数:
0
引用数:
0
h-index:
0
SCHRODER, CH
KAERNER, HC
论文数:
0
引用数:
0
h-index:
0
KAERNER, HC
[J].
JOURNAL OF GENERAL VIROLOGY,
1982,
63
(DEC)
: 315
-
323
[15]
Maniatis T., 1982, MOL CLONING
[16]
MECHANISMS OF ANTIVIRAL IMMUNITY INDUCED BY A VACCINIA VIRUS RECOMBINANT EXPRESSING HERPES-SIMPLEX VIRUS TYPE-1 GLYCOPROTEIN-D - CYTOTOXIC T-CELLS
MARTIN, S
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV TENNESSEE,COLL VET MED,DEPT MICROBIOL,KNOXVILLE,TN 37996
MARTIN, S
MOSS, B
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV TENNESSEE,COLL VET MED,DEPT MICROBIOL,KNOXVILLE,TN 37996
MOSS, B
BERMAN, PW
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV TENNESSEE,COLL VET MED,DEPT MICROBIOL,KNOXVILLE,TN 37996
BERMAN, PW
LASKEY, LA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV TENNESSEE,COLL VET MED,DEPT MICROBIOL,KNOXVILLE,TN 37996
LASKEY, LA
ROUSE, BT
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV TENNESSEE,COLL VET MED,DEPT MICROBIOL,KNOXVILLE,TN 37996
ROUSE, BT
[J].
JOURNAL OF VIROLOGY,
1987,
61
(03)
: 726
-
734
[17]
SYNTHESIS AND PROCESSING OF GLYCOPROTEIN-D OF HERPES-SIMPLEX VIRUS TYPE-1 AND TYPE-2 IN AN INVITRO SYSTEM
MATTHEWS, JT
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV PENN, SCH DENT MED, CTR ORAL HLTH RES, PHILADELPHIA, PA 19104 USA
MATTHEWS, JT
COHEN, GH
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV PENN, SCH DENT MED, CTR ORAL HLTH RES, PHILADELPHIA, PA 19104 USA
COHEN, GH
EISENBERG, RJ
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV PENN, SCH DENT MED, CTR ORAL HLTH RES, PHILADELPHIA, PA 19104 USA
EISENBERG, RJ
[J].
JOURNAL OF VIROLOGY,
1983,
48
(02)
: 521
-
533
[18]
SEQUENCE DETERMINATION AND GENETIC CONTENT OF THE SHORT UNIQUE REGION IN THE GENOME OF HERPES-SIMPLEX VIRUS TYPE-1
MCGEOCH, DJ
论文数:
0
引用数:
0
h-index:
0
MCGEOCH, DJ
DOLAN, A
论文数:
0
引用数:
0
h-index:
0
DOLAN, A
DONALD, S
论文数:
0
引用数:
0
h-index:
0
DONALD, S
RIXON, FJ
论文数:
0
引用数:
0
h-index:
0
RIXON, FJ
[J].
JOURNAL OF MOLECULAR BIOLOGY,
1985,
181
(01)
: 1
-
13
[19]
THE COMPLETE DNA-SEQUENCE OF THE LONG UNIQUE REGION IN THE GENOME OF HERPES-SIMPLEX VIRUS TYPE-1
MCGEOCH, DJ
论文数:
0
引用数:
0
h-index:
0
MCGEOCH, DJ
DALRYMPLE, MA
论文数:
0
引用数:
0
h-index:
0
DALRYMPLE, MA
DAVISON, AJ
论文数:
0
引用数:
0
h-index:
0
DAVISON, AJ
DOLAN, A
论文数:
0
引用数:
0
h-index:
0
DOLAN, A
FRAME, MC
论文数:
0
引用数:
0
h-index:
0
FRAME, MC
MCNAB, D
论文数:
0
引用数:
0
h-index:
0
MCNAB, D
PERRY, LJ
论文数:
0
引用数:
0
h-index:
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PERRY, LJ
SCOTT, JE
论文数:
0
引用数:
0
h-index:
0
SCOTT, JE
TAYLOR, P
论文数:
0
引用数:
0
h-index:
0
TAYLOR, P
[J].
JOURNAL OF GENERAL VIROLOGY,
1988,
69
: 1531
-
1574
[20]
MIMS CA, 1984, VIRAL PATHOGENESIS I, P158
←
1
2
3
4
→