ISLET CELL ANTIGENS IN INSULIN-DEPENDENT DIABETES - PANDORA BOX REVISITED

被引：91

作者：

HARRISON, LC

机构：

[1] Leonard C. Harrison is at the Burnet Clinical Research Unit, Institute of Medical Research, Royal Melbourne Hospital Post Office, Parkville, 3050 Vic., The Walter and Eliza Hall

来源：

IMMUNOLOGY TODAY | 1992年 / 13卷 / 09期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0167-5699(92)90170-C

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A major goal of research into IDDM has been the identification of the 'causative antigen'. As described in this article by Len Harrison, this reductionist aim is confounded by the fact that numerous candidate islet cell antigens have been described. He scrutinizes the credentials of these candidates and discusses the problem of using autoantibodies to identify causative antigens in a T-cell-mediated disease.

引用

页码：348 / 352

页数：5

共 44 条

[1] 64000 MR AUTOANTIBODIES AS PREDICTORS OF INSULIN-DEPENDENT DIABETES [J].

ATKINSON, MA ;

MACLAREN, NK ;

SCHARP, DW ;

LACY, PE ;

RILEY, WJ .

LANCET, 1990, 335 (8702) :1357-1360

[2] RESPONSE OF PERIPHERAL-BLOOD MONONUCLEAR-CELLS TO GLUTAMATE-DECARBOXYLASE IN INSULIN-DEPENDENT DIABETES [J].

ATKINSON, MA ;

KAUFMAN, DL ;

CAMPBELL, L ;

GIBBS, KA ;

SHAH, SC ;

BU, DF ;

ERLANDER, MG ;

TOBIN, AJ ;

MACLAREN, NK .

LANCET, 1992, 339 (8791) :458-459

[3] AUTOANTIBODIES IN NEWLY DIAGNOSED DIABETIC CHILDREN IMMUNOPRECIPITATE HUMAN PANCREATIC-ISLET CELL-PROTEINS [J].

BAEKKESKOV, S ;

NIELSEN, JH ;

MARNER, B ;

BILDE, T ;

LUDVIGSSON, J ;

LERNMARK, A .

NATURE, 1982, 298 (5870) :167-169

[4] ANTIBODIES TO A 64,000 MR HUMAN ISLET CELL ANTIGEN PRECEDE THE CLINICAL ONSET OF INSULIN-DEPENDENT DIABETES [J].

BAEKKESKOV, S ;

LANDIN, M ;

KRISTENSEN, JK ;

SRIKANTA, S ;

BRUINING, GJ ;

MANDRUPPOULSEN, T ;

DEBEAUFORT, C ;

SOELDNER, JS ;

EISENBARTH, G ;

LINDGREN, F ;

SUNDQUIST, G ;

LERNMARK, A .

JOURNAL OF CLINICAL INVESTIGATION, 1987, 79 (03) :926-934

[5] IDENTIFICATION OF THE 64K AUTOANTIGEN IN INSULIN-DEPENDENT DIABETES AS THE GABA-SYNTHESIZING ENZYME GLUTAMIC-ACID DECARBOXYLASE [J].

BAEKKESKOV, S ;

AANSTOOT, HJ ;

CHRISTGAU, S ;

REETZ, A ;

SOLIMENA, M ;

CASCALHO, M ;

FOLLI, F ;

RICHTEROLESEN, H ;

CAMILLI, PD .

NATURE, 1990, 347 (6289) :151-156

[6] QUANTIFICATION OF ISLET-CELL ANTIBODIES AND PREDICTION OF INSULIN-DEPENDENT DIABETES [J].

BONIFACIO, E ;

BINGLEY, PJ ;

SHATTOCK, M ;

DEAN, BM ;

DUNGER, D ;

GALE, EAM ;

BOTTAZZO, GF .

LANCET, 1990, 335 (8682) :147-149

[7] ISLET-CELL ANTIBODIES IN DIABETES-MELLITUS WITH AUTOIMMUNE POLY-ENDOCRINE DEFICIENCIES [J].

BOTTAZZO, GF ;

FLORINCH.A ;

DONIACH, D .

LANCET, 1974, 2 (7892) :1279-1283

[8] INTERFERON-GAMMA ENHANCES THE EXPRESSION OF THE MAJOR HISTOCOMPATIBILITY CLASS-I ANTIGENS ON MOUSE PANCREATIC BETA-CELLS [J].

CAMPBELL, IL ;

WONG, GHW ;

SCHRADER, JW ;

HARRISON, LC .

DIABETES, 1985, 34 (11) :1205-1209

[9] IDENTIFICATION AND CLONING OF A GRANULE AUTOANTIGEN (CARBOXYPEPTIDASE-H) ASSOCIATED WITH TYPE-I DIABETES [J].

CASTANO, L ;

RUSSO, E ;

ZHOU, L ;

LIPES, MA ;

EISENBARTH, GS .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1991, 73 (06) :1197-1201

[10]

CHANG YC, 1988, J NEUROSCI, V8, P2123

← 1 2 3 4 5 →