INHIBITION OF PHOTOHEMOLYSIS BY COPPER(II) COMPLEXES WITH SOD-LIKE ACTIVITY

被引：33

作者：

CONDORELLI, G ^{[1
]}

COSTANZO, LL ^{[1
]}

DEGUIDI, G ^{[1
]}

GIUFFRIDA, S ^{[1
]}

RIZZARELLI, E ^{[1
]}

VECCHIO, G ^{[1
]}

机构：

[1] CNR, IST STUDIO SOSTANZE NAT INTERESSE AGROALIMENTARE, CATANIA, ITALY

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 1994年 / 54卷 / 04期

关键词：

D O I：

10.1016/0162-0134(94)80031-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Red blood cell lysis photosensitized by Ketoprofen, 2-(3-benzoxyphenyl)propionic acid (KPF), was investigated in the presence of some copper(II) complexes with linear and cyclic dipeptides as well as functionalized beta-cyclodextrins with SOD-like activity with the aim of ascertaining their protective activity towards the photoinduced cell damage. The comparison between the decrease of photolytic activity caused by these complexes and their superoxide dismutase activity showed an appreciable correlation. The correct determination of species existing in experimental conditions was obtained through a simulation approach based on the knowledge of the stability constants of the complexes.

引用

页码：257 / 265

页数：9

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