THE INFLUENCE OF H-1-RECEPTOR, H-2-RECEPTOR AND H-3 RECEPTOR ON THE SPONTANEOUS AND CONA INDUCED HISTAMINE-RELEASE FROM HUMAN ADENOIDAL MAST-CELLS

被引：14

作者：

BENT, S ^{[1
]}

FEHLING, U ^{[1
]}

BRAAM, U ^{[1
]}

SCHUNACK, W ^{[1
]}

SCHMUTZLER, W ^{[1
]}

机构：

[1] FREE UNIV BERLIN,INST PHARM,W-1000 BERLIN,GERMANY

来源：

AGENTS AND ACTIONS | 1991年 / 33卷 / 1-2期

关键词：

D O I：

10.1007/BF01993129

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The effects of the H-3-agonist R-alpha-methylhistamine (R-alpha-MeHA) and the H3-antagonist thioperamide on the spontaneous and concanavalin A (ConA) induced histamine release from human mast cells were tested and compared with the effect of some H1- and H2-receptor active substances. R-alpha-MeHA (10(-9) - 10(-7) M) exerted no effect on histamine release whereas thioperamide increased the spontaneous release at 10(-6) - 10(-4) M but inhibited the ConA induced release in a narrow concentration range (10(-6) - 10(-5) M). This enhancement might be taken as an indication of the existence of H3-receptor dependent autoregulation although presently other mechanism cannot be excluded.

引用

页码：67 / 70

页数：4

共 8 条

[1] AUTO-INHIBITION OF BRAIN HISTAMINE-RELEASE MEDIATED BY A NOVEL CLASS (H-3) OF HISTAMINE-RECEPTOR [J].