TAXOL PHOTOAFFINITY LABEL - 7-(PARA-AZIDOBENZOYL)TAXOL SYNTHESIS AND BIOLOGICAL EVALUATION

被引:28
作者
GEORG, GI [1 ]
HARRIMAN, GCB [1 ]
HIMES, RH [1 ]
MEJILLANO, MR [1 ]
机构
[1] UNIV KANSAS,DEPT BIOCHEM,LAWRENCE,KS 66045
关键词
TAXOL; SYNTHESIS; BETA-LACTAMS; MICROTUBULE ASSEMBLY; PHOTOAFFINITY LABEL;
D O I
10.1016/S0960-894X(00)80402-3
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
An efficient semi-synthetic approach utilizing the appropriately functionalized (3R,4S)-3-hydroxy-4-phenyl-2-azetidinone (4) and 7-(p-azidobenzoyl)baccatin III (3) is described which leads to the targeted biologically active taxol photoaffinity label 6
引用
收藏
页码:735 / 738
页数:4
相关论文
共 22 条
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  • [22] 1990, JUN WORKSH TAX TAX C