RADIOSYNTHESIS OF 1-[C-11] POLYHOMOALLYLIC FATTY-ACIDS

被引：36

作者：

CHANNING, MA

SIMPSON, N

机构：

[1] Radiochemistry SectionPET Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, 20892

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1993年 / 33卷 / 06期

关键词：

1-[C-11] LABELED FATTY ACID; 1-[C-11]ARACHIDONIC ACID; 1-[C-11]DOCOSA-HEXAENOIC ACID; RADICAL CHAIN DECARBOXYLATION BROMINATION; (ALL Z)-1-BROMONONADECA-4,7,10,13-TETRAENE; (ALL Z)-1-BROMOHENEICOSA-3,6,9,12,15,18-HEXAENE;

D O I：

10.1002/jlcr.2580330611

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A facile retro-synthesis involving the radical chain decarboxylation of the N-hydroxypyridine-2-thione esters of both arachidonic and docosahexaenoic acid was utilized to synthesize (all Z)-1-bromononadeca-4,7,10,13-tetraene, and (all Z)-1-bromoheneicosa-3,6,9,12,15,18-hexaene in 60% overall yield. The corresponding polyhomoallylic magnesium bromides were carbonated with [C-11]CO2 to afford the 1-[C-11]polyhomoallylic labeled fatty acids in good yield in less than 35 minutes. The final radiochemical purities were found to be in excess of 95% by radio-HPLC.

引用

页码：541 / 546

页数：6

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