CLONING OF A SWELLING-INDUCED CHLORIDE CURRENT RELATED PROTEIN FROM RABBIT HEART

被引：18

作者：

OKADA, H ^{[1
]}

ISHII, K ^{[1
]}

NUNOKI, K ^{[1
]}

TAIRA, N ^{[1
]}

机构：

[1] TOHOKU UNIV,SCH MED,DEPT PHARMACOL,AOBA KU,SENDAI,MIYAGI 980,JAPAN

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 1995年 / 1234卷 / 01期

关键词：

CDNA CLONING; SWELLING-INDUCED CHLORIDE CURRENT; CHLORIDE CURRENT; (RABBIT HEART);

D O I：

10.1016/0005-2736(95)00015-U

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recently, pI(cln), has been reported to be a regulator of a swelling-induced chloride conductance. We have cloned a cDNA RCL-H1 from rabbit heart, of which primary structure is highly homologous to that of pI(cln). Outwardly rectifying currents were recorded in oocytes expressing RCL-H1, which is consistent with the result of pI(cln). RNA blot analysis revealed the widespread expression of RCL-H1 mRNA in rabbit tissues. RCL-H1 may play an important role in regulating cell volume and give a clue to revealing molecular structure of swelling-induced chloride channel(s).

引用

页码：145 / 148

页数：4

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