MOLECULAR-CLONING AND EXPRESSION OF A RAT CDNA-ENCODING MDCK-TYPE CHLORIDE CHANNEL

被引：26

作者：

ABE, T

TAKEUCHI, K

ISHII, K

ABE, K

机构：

[1] TOHOKU UNIV,DEPT INTERNAL MED 2,1-1 SEIRYO MACHI,AOBA KU,SENDAI,MIYAGI 980,JAPAN

[2] TOHOKU UNIV,DEPT CLIN BIOL & HORMONAL REGULAT,SENDAI,MIYAGI 980,JAPAN

[3] TOHOKU UNIV,DEPT PHARMACOL,SENDAI,MIYAGI 980,JAPAN

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1993年 / 1173卷 / 03期

关键词：

CHLORIDE CHANNEL; GENE EXPRESSION; OOCYTE EXPRESSION; A7R5; (XENOPUS); (RAT);

D O I：

10.1016/0167-4781(93)90138-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A cDNA encoding MDCK-type chloride channel was cloned from the rat kidney cDNA library using the homology screening approach. The deduced amino acid sequence of cloned cDNA has a 92.4% homology with the MDCK chloride channel, and electrophysiological analysis using Xenopus oocyte expression system showed the functional character of chloride channel. The rat kidney chloride channel, abbreviated RKCL, is not specific to the kidney, but widely expressed in various tissues. It is suggested that RKCL is important for most cells.

引用

页码：353 / 356

页数：4

共 12 条

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