N-CARBOXYMETHYLCHITOSAN-N,O-SULFATE AS AN ANTI-HIV-1 AGENT

被引:53
作者
SOSA, MAG
FAZELY, F
KOCH, JA
VERCELLOTTI, SV
RUPRECHT, RM
机构
[1] HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV CANC PHARMACOL,44 BINNEY ST,BOSTON,MA 02115
[2] HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115
[3] HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115
[4] HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115
[5] V LABS INC,COVINGTON,LA
关键词
D O I
10.1016/0006-291X(91)91443-G
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
N-carboxymethylchitosan-N-O-sulfate (NCMCS), a sulfated polysaccharide derivative of chitin, inhibited the propagation of the human immunodeficiency virus type 1 (HIV-1) in human CD4+ cells and that of Rauscher murine leukemia virus (RLV) in murine fibroblasts. A dose-dependent inhibition of both viruses was observed without significant cytotoxicity. NCMCS blocked the binding of HIV-1 to human CD4+ target cells and competitively inhibited HIV-1 reverse transcriptase. Thus, NCMCS may prevent HIV-1 infection by inhibiting viral adsorption to the CD4 receptor and reverse transcription of the viral genome. © 1991.
引用
收藏
页码:489 / 496
页数:8
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