N-CARBOXYMETHYLCHITOSAN-N,O-SULFATE AS AN ANTI-HIV-1 AGENT

被引：53

作者：

SOSA, MAG

FAZELY, F

KOCH, JA

VERCELLOTTI, SV

RUPRECHT, RM

机构：

[1] HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV CANC PHARMACOL,44 BINNEY ST,BOSTON,MA 02115

[2] HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115

[3] HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115

[4] HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115

[5] V LABS INC,COVINGTON,LA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 174卷 / 02期

关键词：

D O I：

10.1016/0006-291X(91)91443-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

N-carboxymethylchitosan-N-O-sulfate (NCMCS), a sulfated polysaccharide derivative of chitin, inhibited the propagation of the human immunodeficiency virus type 1 (HIV-1) in human CD4+ cells and that of Rauscher murine leukemia virus (RLV) in murine fibroblasts. A dose-dependent inhibition of both viruses was observed without significant cytotoxicity. NCMCS blocked the binding of HIV-1 to human CD4+ target cells and competitively inhibited HIV-1 reverse transcriptase. Thus, NCMCS may prevent HIV-1 infection by inhibiting viral adsorption to the CD4 receptor and reverse transcription of the viral genome. © 1991.

引用

页码：489 / 496

页数：8

共 41 条

[11]

DECLERCQ E, 1990, 6 INT C AIDS SAN FRA, V1, P179

[12] SYNTHESIS OF AN INHIBITOR OF HUMAN IMMUNODEFICIENCY VIRUS-INFECTION [J].