RADIOACTIVE GOLD CLUSTER IMMUNOCONJUGATES - POTENTIAL AGENTS FOR CANCER-THERAPY

被引：25

作者：

HAINFELD, JF

FOLEY, CJ

SRIVASTAVA, SC

MAUSNER, LF

FENG, NI

MEINKEN, GE

STEPLEWSKI, Z

机构：

[1] BROOKHAVEN NATL LAB, DEPT MED, UPTON, NY 11973 USA

[2] WISTAR INST, PHILADELPHIA, PA 19104 USA

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1990年 / 17卷 / 03期

关键词：

D O I：

10.1016/0883-2897(90)90054-5

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

An 11 gold atom (undecagold) cluster was covalently attached to specific sites on Fab′, F(ab′)2 and whole IgG molecules such that each carried 11-33 gold atoms without significant loss of native immunospecificity. Gold cluster labeled 17-1A monoclonal F(ab′)2 antibody fragments showed 80% immunoreactivity compared to native antibody fragments in binding to human colon carcinoma cells in vitro. Radioactive gold in vivo biodistributions in nude mice with human tumors are also reported. By using clusters, potentially a larger destructive payload can be carried per antibody. © 1990.

引用

页码：287 / +

页数：1

共 22 条

[11]

LEIBOVITZ A, 1976, CANCER RES, V36, P4562

[12] DOSIMETRY AND TREATMENT PLANNING FOR Y-90-LABELED ANTIFERRITIN IN HEPATOMA [J].

LEICHNER, PK ;

YANG, NC ;

FRENKEL, TL ;

LOUDENSLAGER, DM ;

HAWKINS, WG ;

KLEIN, JL ;

ORDER, SE .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1988, 14 (05) :1033-1042

[13]

OKINAKA Y, 1980, Patent No. 4222996

[14]

ORDER SE, 1988, ANTIBODY IMMUNOCONJ, V1, P163

[15]

PAIK CH, 1983, J NUCL MED, V24, P1158

[16]

PAIK CH, 1983, J NUCL MED, V24, P932

[17]

PARHAM P, 1983, J IMMUNOL, V131, P2895

[18] UNDECAGOLD CLUSTERS FOR SITE-SPECIFIC LABELING OF BIOLOGICAL MACROMOLECULES - SIMPLIFIED PREPARATION AND MODEL APPLICATIONS [J].

SAFER, D ;

BOLINGER, L ;

LEIGH, JS .

JOURNAL OF INORGANIC BIOCHEMISTRY, 1986, 26 (02) :77-91

[19]

Srivastava S. C., 1988, RADIOLABELED MONOCLO

[20]

SUTHERLAND R, 1987, CANCER RES, V47, P1627

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