INTEGRATION OF GENE MAPS - CHROMOSOME-1

被引：56

作者：

COLLINS, A ^{[1
]}

KEATS, BJ ^{[1
]}

DRACOPOLI, N ^{[1
]}

SHIELDS, DC ^{[1
]}

MORTON, NE ^{[1
]}

机构：

[1] LOUISIANA STATE UNIV CTR,DEPT BIOMETRY & GENET,NEW ORLEANS,LA 70112

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 10期

关键词：

HUMAN GENOME; LINKAGE;

D O I：

10.1073/pnas.89.10.4598

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A composite map of 177 loci has been constructed in two steps. The first combined pairwise logarithm-of-odds scores on 127 loci into a comprehensive genetic map. Then this map was projected onto the physical map through cytogenetic assignments, and the small amount of physical data was interpolated for an additional 50 loci each of which had been assigned to an interval of less than 10 megabases. The resulting composite map is on the physical scale with a resolution of 1.5 megabases. In the future these methods may be used to incorporate locations from linkage, contigs, radiation hybrids, restriction fragments, and somatic cell maps. Dense, reliable, and well-documented maps are essential for long-range sequencing and to localize and clone disease genes.

引用

页码：4598 / 4602

页数：5

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