CHARACTERIZATION OF NORMAL BRAIN-REACTIVE ANTIBODIES IN GLIOMA CYST FLUIDS

被引：7

作者：

BRUNET, JFM

BERGER, F

GUSTIN, T

LAINE, M

BENABID, AL

机构：

[1] INSERM, U318, NEUROBIOPHYS LAB, GRENOBLE, FRANCE

[2] CLIN UNIV ST LUC, SERV NEUROCHIRURG, B-1200 BRUSSELS, BELGIUM

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1993年 / 47卷 / 01期

基金：

澳大利亚研究理事会;

关键词：

BRAIN CYST FLUID; AUTOANTIBODY; BLOOD BRAIN BARRIER; BRAIN EDEMA;

D O I：

10.1016/0165-5728(93)90285-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Anti-normal brain antibodies were studied in glioma cyst fluids. Cyst fluids were obtained by stereotaxic puncture from 34 patients with cystic gliomas. Immunoglobulins were analyzed by immunohistochemistry, immuno-Western blotting, concentration measures, and isoelectrofocalization. 80% of cyst fluids stained astrocytes and/or microvessels in non-tumoral white matter. In white matter extracts, cyst fluids recognized five immunoreactive bands having apparent molecular masses of 50-75 kDa. Although cyst proteins could be of systemic origin, isoelectrofocalization analysis suggests an additional local immune response. These antibody activities could be involved in certain peritumoral events such as brain edema.

引用

页码：63 / 72

页数：10

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[11] ASTROCYTES PRESENT MYELIN BASIC-PROTEIN TO ENCEPHALITOGENIC T-CELL LINES [J].