LEUCINE-RESPONSIVE REGULATORY PROTEIN - A GLOBAL REGULATOR OF GENE-EXPRESSION IN ESCHERICHIA-COLI

被引：135

作者：

NEWMAN, EB ^{[1
]}

LIN, RT ^{[1
]}

机构：

[1] LADY DAVIS INST MED RES,MONTREAL,PQ H3T 1E2,CANADA

来源：

ANNUAL REVIEW OF MICROBIOLOGY | 1995年 / 49卷

关键词：

TRANSCRIPTION REGULATION; DNA-BINDING PROTEINS; CHROMOSOME STRUCTURE;

D O I：

10.1146/annurev.mi.49.100195.003531

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The leucine-responsive regulatory protein (Lrp) regulates transcription of the many genes of the Lrp regulon, repressing some and activating others, some in response to L-leucine and some independent of it. The physiology and molecular biology of the regulon in Escherichia coli are summarized here. However, the high degree of conservation of the protein suggests that it has an important role in all enterobacteria. We suggest that this role is not only as a transcriptional regulator but also as a determinant of chromosome structure.

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页码：747 / 775

页数：29

相关论文

共 114 条

[1] PROMOTER RESURRECTION BY ACTIVATORS - A MINIREVIEW [J].

ADHYA, S ;

GOTTESMAN, M ;

GARGES, S ;

OPPENHEIM, A .

GENE, 1993, 132 (01) :1-6

[2] NEUTRALIZATION OF AMINO ACID SENSITIVITY OF RCREL ESCHERICHIA COLI [J].

ALFOLDI, L ;

KEREKES, E .

BIOCHIMICA ET BIOPHYSICA ACTA, 1964, 91 (01) :155-&

[3]

AMBARTSOUMIAN G, 1994, MICROBIOLOGY, V148, P1737

[4] MAPPING OF 2 LOCI AFFECTING REGULATION OF BRANCHED-CHAIN AMINO-ACID TRANSPORT IN ESCHERICHIA-COLI K-12 [J].

ANDERSON, JJ ;

QUAY, SC ;

OXENDER, DL .

JOURNAL OF BACTERIOLOGY, 1976, 126 (01) :80-90

[5] ESCHERICHIA-COLI TRANSPORT MUTANTS LACKING BINDING-PROTEIN AND OTHER COMPONENTS OF BRANCHED-CHAIN AMINO-ACID TRANSPORT-SYSTEMS [J].

ANDERSON, JJ ;

OXENDER, DL .

JOURNAL OF BACTERIOLOGY, 1977, 130 (01) :384-392

[6] REGULATION OF PEPTIDE-TRANSPORT IN ESCHERICHIA-COLI - INDUCTION OF THE TRP-LINKED OPERON ENCODING THE OLIGOPEPTIDE PERMEASE [J].

ANDREWS, JC ;

BLEVINS, TC ;

SHORT, SA .

JOURNAL OF BACTERIOLOGY, 1986, 165 (02) :428-433

[7] OPP-LAC OPERON FUSIONS AND TRANSCRIPTIONAL REGULATION OF THE ESCHERICHIA-COLI TRP-LINKED OLIGOPEPTIDE PERMEASE [J].

ANDREWS, JC ;

SHORT, SA .

JOURNAL OF BACTERIOLOGY, 1986, 165 (02) :434-442

[8]

ARST HN, 1994, NATURE, V262, P231

[9]

AUSTIN EA, 1989, MOL GENETICS BACTERI, P153

[10] PROMOTERS OF THE MALEFG AND MALK-LAMB OPERONS IN ESCHERICHIA-COLI-K12 [J].

BEDOUELLE, H ;

SCHMEISSNER, U ;

HOFNUNG, M ;

ROSENBERG, M .

JOURNAL OF MOLECULAR BIOLOGY, 1982, 161 (04) :519-531

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