THE SYNTHESIS AND BIOLOGICAL-ACTIVITY OF ENEDIYNE MINOR-GROOVE BINDING HYBRIDS

被引：26

作者：

WITTMAN, MD ^{[1
]}

KADOW, JF ^{[1
]}

LANGLEY, DR ^{[1
]}

VYAS, DM ^{[1
]}

ROSE, WC ^{[1
]}

SOLOMON, W ^{[1
]}

ZEIN, N ^{[1
]}

机构：

[1] BRISTOL MYERS SQUIBB CO,PHARMACEUT RES INST,ONCOL DRUG DISCOVERY,PRINCETON,NJ 08543

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 10期

关键词：

D O I：

10.1016/0960-894X(95)00163-N

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The potential for increasing the antitumor potency of a synthetic bicyclic enediyne by attaching a DNA recognition element has been investigated and the hybrids evaluated for antitumor activity.

引用

页码：1049 / 1052

页数：4

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