ACULEOSIDE-A, A NOVEL STEROIDAL SAPONIN CONTAINING A DEOXYALDOKETOSE FROM RUSCUS-ACULEATUS

被引：12

作者：

HORIKAWA, T

MIMAKI, Y

KAMEYAMA, A

SASHIDA, Y

NIKAIDO, T

OHMOTO, T

机构：

[1] TOKYO COLL PHARM, HACHIOJI, TOKYO 19203, JAPAN

[2] TOHO UNIV, SCH PHARMACEUT SCI, FUNABASHI, CHIBA 274, JAPAN

来源：

CHEMISTRY LETTERS | 1994年 / 12期

关键词：

D O I：

10.1246/cl.1994.2303

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

A novel steroidal saponin, named aculeoside A, embracing a deoxyaldoketose, 6-deoxy-D-glycero-L-threo-4-hexosulose, was isolated from the underground parts of Ruscus aculeatus. The structure was determined by extensive 2D NMR analysis and hydrolysis. Aculeoside A was active as a cyclic AMP phosphodiesterase inhibitor.

引用

收藏

页码：2303 / 2306

页数：4

相关论文

共 7 条

[1]

C-13 NMR SPECTRAL INVESTIGATIONS .10. C-13 NMR-SPECTROSCOPY OF STEROIDAL SAPOGENINS AND STEROIDAL SAPONINS [J].

AGRAWAL, PK ;

JAIN, DC ;

GUPTA, RK ;

THAKUR, RS .

PHYTOCHEMISTRY, 1985, 24 (11) :2479-2496

[2]

ESMANN M, 1988, METHOD ENZYMOL, V156, P105

[3]

ISOLATION OF PSEUDOPROTOTIMOSAPONIN-AIII FROM RHIZOMES OF ANEMARRHENA-ASPHODELOIDES AND ITS HYPOGLYCEMIC ACTIVITY IN STREPTOZOTOCIN-INDUCED DIABETIC MICE [J].

NAKASHIMA, N ;

KIMURA, I ;

KIMURA, M ;

MATSUURA, H .

JOURNAL OF NATURAL PRODUCTS, 1993, 56 (03) :345-350

[4]

INHIBITORS OF CYCLIC-AMP PHOSPHODIESTERASE IN MEDICINAL-PLANTS [J].

NIKAIDO, T ;

OHMOTO, T ;

NOGUCHI, H ;

KINOSHITA, T ;

SAITOH, H ;

SANKAWA, U .

PLANTA MEDICA, 1981, 43 (01) :18-23

[5]

SCREENING-TEST FOR PLATELET-AGGREGATION INHIBITOR IN NATURAL-PRODUCTS - THE ACTIVE PRINCIPLE OF ANEMARRHENAE RHIZOMA [J].

NIWA, A ;

TAKEDA, O ;

ISHIMARU, M ;

NAKAMOTO, Y ;

YAMASAKI, K ;

KOHDA, H ;

NISHIO, H ;

SEGAWA, T ;

FUJIMURA, K ;

KURAMOTO, A .

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 1988, 108 (06) :555-561

[6]

RESOLUTION OF THE ENANTIOMERS OF ALDOSES BY LIQUID-CHROMATOGRAPHY OF DIASTEREOISOMERIC 1-(N-ACETYL-ALPHA-METHYLBENZYLAMINO)-1-DEOXYALDITOL ACETATES [J].

OSHIMA, R ;

YAMAUCHI, Y ;

KUMANOTANI, J .

CARBOHYDRATE RESEARCH, 1982, 107 (02) :169-176

[7]

WU RT, 1990, INT J IMMUNOPHARMACO, V12, P777