ISOLATION OF PSEUDOPROTOTIMOSAPONIN-AIII FROM RHIZOMES OF ANEMARRHENA-ASPHODELOIDES AND ITS HYPOGLYCEMIC ACTIVITY IN STREPTOZOTOCIN-INDUCED DIABETIC MICE

被引：100

作者：

NAKASHIMA, N

KIMURA, I

KIMURA, M

MATSUURA, H

机构：

[1] TOYAMA MED & PHARMACEUT UNIV,FAC PHARMACEUT SCI,DEPT CHEM PHARMACOL,TOYAMA,TOYAMA 93001,JAPAN

[2] WAKUNAGA PHARMACEUT CO LTD,INST OTC,HIROSHIMA,JAPAN

来源：

JOURNAL OF NATURAL PRODUCTS | 1993年 / 56卷 / 03期

关键词：

D O I：

10.1021/np50093a006

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A hot-H2O extract of rhizomes of Anemarrhena asphodeloides, the Japanese sino-medicine ''chimo,'' lowered the blood glucose level in alloxan-diabetic mice. Hypoglycemic activity-guided fractionation isolated a new glycoside, pseudoprototimosaponin AIII [1], which was compared with chemically known prototimosaponin AIII [2]. These compounds exhibited hypoglycemic effects in a dose-dependent manner in streptozotocin-diabetic mice but showed no effects on glucose uptake and insulin release, suggesting that the hypoglycemic mechanism may be due to inhibition of hepatic gluconeogenesis and/or glycogenolysis.

引用

页码：345 / 350

页数：6

共 25 条

[1]

BIN HK, 1930, NIPPON YAKUBUTSUGAKA, V11, P22

[2]

BOID AE, 1988, DIABETES, V37, P847

[3]

HELLMAN B, 1975, HDB EXPTL PHARMACOLO, V32, P175

[4]

HIRAI Y, 1986, CHEM PHARM BULL, V34, P82

[5]

KAWASAKI T, 1963, Chem Pharm Bull (Tokyo), V11, P1221

[6] SALIVARY PEPTIDE P-C MODULATES BOTH INSULIN AND GLUCAGON-RELEASE FROM ISOLATED PERFUSED RAT PANCREAS [J].

KIMURA, M ;

NAKASHIMA, N ;

KIMURA, I .

JAPANESE JOURNAL OF PHARMACOLOGY, 1990, 52 (04) :579-585

[7] PHARMACOLOGICAL SEQUENTIAL TRIALS FOR THE FRACTIONATION OF COMPONENTS WITH HYPOGLYCEMIC ACTIVITY IN ALLOXAN DIABETIC MICE FROM GINSENG RADIX [J].

KIMURA, M ;

WAKI, I ;

TANAKA, O ;

NAGAI, Y ;

SHIBATA, S .

JOURNAL OF PHARMACOBIO-DYNAMICS, 1981, 4 (06) :402-409

[8] EFFECTS OF HYPOGLYCEMIC COMPONENTS IN GINSENG RADIX ON BLOOD INSULIN LEVEL IN ALLOXAN DIABETIC MICE AND ON INSULIN RELEASE FROM PERFUSED RAT PANCREAS [J].

KIMURA, M ;

WAKI, I ;

CHUJO, T ;

KIKUCHI, T ;

HIYAMA, C ;

YAMAZAKI, K ;

TANAKA, O .

JOURNAL OF PHARMACOBIO-DYNAMICS, 1981, 4 (06) :410-417

[9]

Kimura M, 1967, Nihon Rinsho, V25, P2841

[10] DIABETIC STATE-INDUCED MODIFICATION OF INSULIN-STIMULATED, GLUCOSE-UPTAKE INTO AND KINASE-ACTIVITY IN, THE DIAPHRAGM MUSCLE OF GENETICALLY DIABETIC KK-CA(Y) MICE [J].

KIMURA, M ;

NAITOH, T ;

KOBAYASHI, S ;

KIMURA, I .

JOURNAL OF PHARMACOBIO-DYNAMICS, 1992, 15 (01) :17-23

← 1 2 3 →