ANTAGONISM OF MORPHINE-INDUCED CATALEPSY BY L-PROLYL-L-LEUCYL-GLYCINAMIDE

被引：44

作者：

CHIU, S ^{[1
]}

MISHRA, RK ^{[1
]}

机构：

[1] MCMASTER UNIV,DEPT NEUROSCI,HAMILTON L8S 4J9,ONTARIO,CANADA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 53卷 / 02期

关键词：

(PLG); (TRH); Catalepsy; L-Prolyl-leucyl-glycinamide; Morphine; Parkinsonism; Thyrotropin releasing hormone;

D O I：

10.1016/0014-2999(79)90156-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In vew of the recently demonstrated extra-endocrine central actions of hypothalamic releasing hormones, we have investigated the effects of prolyl-leucyl-glycinamide (PLG) and thyrotropin releasing hormone (TRH) on morphine-induced catalepsy. Although acute administration of PLG (10 mg kg- s.c.) slightly attenuated the cataleptic response, chronic PLG treatment (10 mg kg- s.c. for 10 days) virtually abolished morphine-induced catalepsy. TRH, administered subcutaneously, exhibited little or no anti-cataleptic activity. These results are discussed in relation to the possible central site of narcotic-induced catalepsy and the therapeutic potential of PLG in Parkinson's disease. © 1979.

引用

页码：119 / 125

页数：7