DICTYOSTELIUM CELLS PRODUCE PLATELET-ACTIVATING-FACTOR IN RESPONSE TO CAMP

被引：24

作者：

BUSSOLINO, F

SORDANO, C

BENFENATI, E

BOZZARO, S

机构：

[1] UNIV TURIN,DEPT CLIN & BIOL SCI,I-10124 TURIN,ITALY

[2] DEPT GENET BIOL & MED CHEM,TURIN,ITALY

[3] MARIO NEGRI INST PHARMACOL RES,I-20157 MILAN,ITALY

来源：

EUROPEAN JOURNAL OF BIOCHEMISTRY | 1991年 / 196卷 / 03期

关键词：

D O I：

10.1111/j.1432-1033.1991.tb15856.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Evidence is provided that Dictyostelium discoideum cells produce 1-O-alkyl-2-delta-acetyl-O-sn-glycero-3-phosphocholine (platelet-activating factor, PAF). D. discoideum PAF has been characterized as being identical with mammalian platelet-activating factor, based on its stimulation of rabbit platelet aggregation, its physicochemical properties and mass spectrum. The basal activity of PAF increases after starvation and during aggregation and declines at the slug stage. PAF is not detected in the extracellular space. Cell treatment with cAMP pulses stimulates a transient accumulation of PAF, probably via activation of a cAMP-dependent acetyltransferase, suggesting a possible involvement of PAF in cAMP-regulated processes in Dictyostelium.

引用

页码：609 / 615

页数：7

共 56 条

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