COMPUTER-SIMULATION OF A CYTOSOLIC CALCIUM OSCILLATOR

被引:49
作者
SWILLENS, S
MERCAN, D
机构
[1] Inst. Rech. Interdisciplinaire, Universite Libre de Bruxelles, Campus Erasme, 1070 Brussels
关键词
D O I
10.1042/bj2710835
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A new interpretation of existing data permits us to define a model capable of accounting for agonist-induced Ca2+ oscillations in the cytosol of electrically non-excitable cells. The model only requires one Ca2+ store, which contains Ca2+ channels controlled by inositol 1,4,5-trisphosphate and Ca2+. Computer simulations may generate different experimentally observed patterns of Ca2+ oscillations.
引用
收藏
页码:835 / 838
页数:4
相关论文
共 22 条
[1]   INOSITOL PHOSPHATES AND CELL SIGNALING [J].
BERRIDGE, MJ ;
IRVINE, RF .
NATURE, 1989, 341 (6239) :197-205
[2]   CYTOSOLIC CALCIUM OSCILLATORS [J].
BERRIDGE, MJ ;
GALIONE, A .
FASEB JOURNAL, 1988, 2 (15) :3074-3082
[3]   MYOINOSITOL 1,4,5-TRISPHOSPHOROTHIOATE IS A POTENT COMPETITIVE INHIBITOR OF HUMAN-ERYTHROCYTE 5-PHOSPHATASE [J].
COOKE, AM ;
NAHORSKI, SR ;
POTTER, BVL .
FEBS LETTERS, 1989, 242 (02) :373-377
[4]   MINIMAL MODEL FOR SIGNAL-INDUCED CA-2+ OSCILLATIONS AND FOR THEIR FREQUENCY ENCODING THROUGH PROTEIN-PHOSPHORYLATION [J].
GOLDBETER, A ;
DUPONT, G ;
BERRIDGE, MJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (04) :1461-1465
[5]   INOSITOL TETRAKISPHOSPHATE-INDUCED SEQUESTRATION OF CA-2+ REPLENISHES AN INTRACELLULAR POOL SENSITIVE TO INOSITOL TRISPHOSPHATE [J].
HILL, TD ;
BOYNTON, AL .
JOURNAL OF CELLULAR PHYSIOLOGY, 1990, 142 (01) :163-169
[6]  
INESI G, 1980, J BIOL CHEM, V255, P3025
[7]   THE EFFECT OF EXTERNAL CALCIUM AND PH ON INOSITOL TRISPHOSPHATE-MEDIATED CALCIUM RELEASE FROM CEREBELLUM MICROSOMAL FRACTIONS [J].
JOSEPH, SK ;
RICE, HL ;
WILLIAMSON, JR .
BIOCHEMICAL JOURNAL, 1989, 258 (01) :261-265
[8]  
KAWANISHI T, 1989, J BIOL CHEM, V264, P12859
[9]   KINETICS OF CALCIUM-CHANNEL OPENING BY INOSITOL 1,4,5-TRISPHOSPHATE [J].
MEYER, T ;
WENSEL, T ;
STRYER, L .
BIOCHEMISTRY, 1990, 29 (01) :32-37
[10]   MOLECULAR-MODEL FOR RECEPTOR-STIMULATED CALCIUM SPIKING [J].
MEYER, T ;
STRYER, L .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (14) :5051-5055