IDENTIFICATION AND LOCALIZATION OF THE MYOTONIC-DYSTROPHY GENE-PRODUCT IN SKELETAL AND CARDIAC MUSCLES

被引:26
作者
SALVATORI, S [1 ]
BIRAL, D [1 ]
FURLAN, S [1 ]
MARIN, O [1 ]
机构
[1] UNIV PADUA,CTR CRIBI BIOTECHNOL,I-35121 PADUA,ITALY
关键词
D O I
10.1006/bbrc.1994.2335
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We have raised a polyclonal antibody against a synthetic peptide chosen within the deduced sequence of the myotonic dystrophy gene product. This antibody binds to a protein whose molecular weight is in the range of 50-54 kDa in Western blotting of rat, rabbit and human muscles. Biochemical studies seem to indicate that this protein is a peripheral component of sarcoplasmic reticulum as well as of plasma membrane. (C) 1994 Academic Press, Inc.
引用
收藏
页码:1365 / 1370
页数:6
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