PLECKSTRIN HOMOLOGY DOMAINS - A FACT FILE

被引：86

作者：

SARASTE, M

HYVONEN, M

机构：

[1] EMBL, D-69012 Heidelberg

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1995年 / 5卷 / 03期

关键词：

D O I：

10.1016/0959-440X(95)80104-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Structures of three different pleckstrin homology domains have been determined within the past year. They have a common core consisting of a seven-stranded and strongly bent beta-sheet and a C-terminal alpha-helix that packs against the beta-sheet. Phosphatidylinositol 4,5-bisphosphate and related compounds specifically bind to pleckstrin homology domains, suggesting that the domain may be involved in reversible anchorage to membranes or in recognition of a second messenger, such as inositol 1,4,5-trisphosphate, Pleckstrin homology domains have also been suggested to bind to the G(beta gamma) complex, but direct evidence for this is missing.

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页码：403 / 408

页数：6

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