FIBROGENESIS IN CIRRHOSIS - POTENTIAL FOR THERAPEUTIC INTERVENTION

被引:18
作者
ROJKIND, M
机构
[1] Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY
关键词
D O I
10.1016/0163-7258(92)90045-2
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Liver cirrhosis is an end stage of several diseases that affect the liver chronically. It is characterized, among other things, by excess collagen deposition, distortion of liver architecture, tissue malfunction and hemodynamic alterations. Many of the complications of cirrhosis may result from excess matrix deposition. Therefore, prevention of collagen accumulation or removal of collagen deposits could ameliorate the disease. In this article we discuss the pathophysiology of liver fibrosis and we describe various compounds with antiinflammatory and antifibrogenic activity. We discuss their possible mechanism of action and we describe animal and clinical studies in which these compounds have been utilized.
引用
收藏
页码:81 / 104
页数:24
相关论文
共 239 条
[71]   HEPATOTOXICITY IN A RAT MODEL CAUSED BY ORALLY-ADMINISTERED METHOTREXATE [J].
HALL, PD ;
JENNER, MA ;
AHERN, MJ .
HEPATOLOGY, 1991, 14 (05) :906-910
[72]  
HAMALAINEN L, 1985, J BIOL CHEM, V260, P720
[73]   EFFECTS OF COLCHICINE ON COLLAGENASE IN CULTURES OF RHEUMATOID SYNOVIUM [J].
HARRIS, ED ;
KRANE, SM .
ARTHRITIS AND RHEUMATISM, 1971, 14 (06) :669-+
[75]  
HEIDEL JR, 1989, AM J PATHOL, V134, P671
[76]   INTERLEUKIN-6 AND THE ACUTE PHASE RESPONSE [J].
HEINRICH, PC ;
CASTELL, JV ;
ANDUS, T .
BIOCHEMICAL JOURNAL, 1990, 265 (03) :621-636
[77]  
HIRAYAMA C, 1968, CLIN CHIM ACTA, V21, P49
[78]  
HOFMANN AF, 1987, LANCET, V2, P398
[79]  
HOOFNAGLE JH, 1984, GASTROENTEROLOGY, V86, P150
[80]   TREATMENT OF CHRONIC NON-A,NON-B HEPATITIS WITH RECOMBINANT HUMAN ALPHA-INTERFERON - A PRELIMINARY-REPORT [J].
HOOFNAGLE, JH ;
MULLEN, KD ;
JONES, DB ;
RUSTGI, V ;
DIBISCEGLIE, A ;
PETERS, M ;
WAGGONER, JG ;
PARK, Y ;
JONES, EA .
NEW ENGLAND JOURNAL OF MEDICINE, 1986, 315 (25) :1575-1578