THE ROLE OF TUMOR-NECROSIS-FACTOR RECEPTORS IN CELL SIGNALING AND THE SIGNIFICANCE OF SOLUBLE FORM LEVELS IN THE SERUM

被引：12

作者：

ABE, Y

WATANABE, Y

KIMURA, S

机构：

[1] The Second Department of Surgery, Ehime University School of Medicine

来源：

SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY | 1994年 / 24卷 / 03期

关键词：

TUMOR NECROSIS FACTOR; RECEPTOR; SIGNALING; SERUM LEVEL;

D O I：

10.1007/BF02032887

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Two types of tumor necrosis factor membrane receptors (TNF-R) have been identified, namely 55 and 75 kDa TNF-R. Soluble forms of these receptors are present in the human serum. Recent findings on the role of these two TNF-R in biological cell signaling and the clinical significance of the serum levels of soluble TNF-R (sTNF-R) were reviewed. It is not the uptake of TNF molecules into cells but rather the molecular capping of TNF-R on the cell membrane that initiates the biological activity of TNF. The 55 kDa TNF-R mediates major bioactivities of TNF, while the significance of 75 kDa TNF-R remains unclear. We herein suggest a new concept of the role of these two TNF-R: The 75 kDa TNF-R signal appeared to enhance that of 55 kDa TNF-R in the induction of ICAM-1 expression on HL-60 human promyelocytic leukemic cells. High serum levels of sTNF-R are reported in patients with malignancy, endotoxin shock, pneumonia, and autoimmune diseases. However, the source of elevated serum sTNF-R remains unclear. Studies on the clinical usefulness of serum sTNF-R levels as cancer and inflammation markers are now being carried out.

引用

页码：197 / 202

页数：6

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