BONE MORPHOGENETIC PROTEIN - CHROMOSOMAL LOCALIZATION OF HUMAN GENES FOR BMP1, BMP2A, AND BMP3

被引：74

作者：

TABAS, JA

ZASLOFF, M

WASMUTH, JJ

EMANUEL, BS

ALTHERR, MR

MCPHERSON, JD

WOZNEY, JM

KAPLAN, FS

机构：

[1] HOSP UNIV PENN,DEPT ORTHOPAED SURG,SILVERSTEIN 2,3400 SPRUCE ST,PHILADELPHIA,PA 19104

[2] UNIV PENN,SCH MED,DEPT ORTHOPAED SURG,PHILADELPHIA,PA 19104

[3] CHILDRENS HOSP PHILADELPHIA,DIV HUMAN GENET & MOLEC BIOL,PHILADELPHIA,PA 19104

[4] GENET INST,TISSUE GROWTH & REPAIR PROGRAM,CAMBRIDGE,MA 02140

[5] UNIV CALIF IRVINE,COLL MED,DEPT BIOL CHEM,IRVINE,CA 92717

来源：

GENOMICS | 1991年 / 9卷 / 02期

关键词：

D O I：

10.1016/0888-7543(91)90254-C

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Bone morphogenetic protein (BMP) induces endochondral bone formation in vivo. The human genes have been cloned for a group of proteins containing BMP activity (BMP1, BMP2A, and BMP3). Two of the proteins are members of the transforming growth factor-β supergene family (BMP2A and BMP3), while BMP1 is a novel regulatory protein. Using somatic cell hybrid lines, cDNA probes were used to map BMP1 to chromosome 8, BMP2A to chromosome 20, and BMP3 to the p14-q21 region of chromosome 4. This analysis reveals that the BMP2A and BMP3 genes map to conserved regions between mouse and human, while the BMP1 gene does not. The locations of the BMP genes were found to overlap with the loci for several disorders of cartilage and bone formation. © 1991.

引用

页码：283 / 289

页数：7