ANAL CANCER

被引:41
作者
CUMMINGS, BJ
机构
[1] Department of Radiation Oncology, The Princess Margaret Hospital, M4X I K9, 500 Sherbourne Street, Toronto, Ontario
来源
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 1990年 / 19卷 / 05期
关键词
Anal canal cancer; Perianal cancer; Radiation; Radiation and chemotherapy;
D O I
10.1016/0360-3016(90)90250-N
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Combined modality treatment with radiation, chemotherapy, and conservative surgery controls most epidermoid cancers of the anal canal and advanced squamous cell cancers of the perianal skin. Anorectal function is preserved in about 70% of patients or more. Five-year survival rates are similar to those previously obtained with radical surgery or radical radiation therapy. The cytotoxic drugs 5-Fluorouracil and Mitomycin C are frequently given concurrently with radiation, but other effective regimens have also been described. The mechanisms of interaction of radiation and cytotoxic drugs in the treatment of anal cancer are not known. © 1990.
引用
收藏
页码:1309 / 1315
页数:7
相关论文
共 61 条
[31]   CANCER OF THE ANAL-CANAL - MODEL FOR PREOPERATIVE ADJUVANT COMBINED MODALITY THERAPY [J].
LEICHMAN, L ;
NIGRO, N ;
VAITKEVICIUS, VK ;
CONSIDINE, B ;
BUROKER, T ;
BRADLEY, G ;
SEYDEL, HG ;
OLCHOWSKI, S ;
CUMMINGS, G ;
LEICHMAN, C ;
BAKER, L .
AMERICAN JOURNAL OF MEDICINE, 1985, 78 (02) :211-215
[32]  
LEICHMAN L, 1989, ANAL CANCER CURRENT
[33]  
Lindell T D, 1974, Am Surg, V40, P281
[34]  
MAGILL GB, 1989, P AN M AM SOC CLIN, V8, P117
[35]  
MICHAELSON RA, 1983, CANCER, V51, P390, DOI 10.1002/1097-0142(19830201)51:3<390::AID-CNCR2820510306>3.0.CO
[36]  
2-V
[37]  
MORSON BC, 1976, INT HISTOLOGICAL CLA, V15, P62
[38]  
Nigro N D, 1989, Important Adv Oncol, P161
[40]   COMBINED THERAPY FOR CANCER OF ANAL-CANAL - PRELIMINARY REPORT [J].
NIGRO, ND ;
VAITKEVICIUS, VK ;
CONSIDINE, B .
DISEASES OF THE COLON & RECTUM, 1974, 17 (03) :354-356