SYNTHETIC STUDIES ON DUOCARMYCIN .2. SYNTHESIS AND CYTOTOXICITY OF NATURAL (+)-DUOCARMYCIN-A AND ITS 3 POSSIBLE STEREOISOMERS

被引：22

作者：

FUKUDA, Y

NAKATANI, K

TERASHIMA, S

机构：

[1] SAGAMI CHEM RES CTR,SAGAMIHARA,KANAGAWA 229,JAPAN

[2] KYORIN PHARMACEUT CO LTD,CENT RES LABS,NOGI,TOCHIGI 32901,JAPAN

来源：

TETRAHEDRON | 1994年 / 50卷 / 09期

关键词：

(+)-DUOCARMYCIN A; (+)-2-EPIDUOCARMYCIN A; TOTAL SYNTHESIS; ANTITUMOR ANTIBIOTIC; CYTOTOXICITY;

D O I：

10.1016/S0040-4020(01)86994-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The title synthesis was achieved by featuring the optical resolution of two types of the tricyclic intermediates and the synthetic scheme established in the synthesis of racemic compounds. In vitro cytotoxicity assay against P388 murine leukemia obviously showed that the absolute configuration of cyclopropane moiety in (+)-1 is closely related to its cytotoxicity.

引用

收藏

页码：2809 / 2820

页数：12

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