DESIGN, SYNTHESIS, AND EVALUATION OF DNA MINOR-GROOVE BINDING-AGENTS

被引：30

作者：

BOGER, DL

机构：

[1] The Scripps Research Institute, Department of Chemistry, La Jolla, California

来源：

PURE AND APPLIED CHEMISTRY | 1993年 / 65卷 / 06期

关键词：

D O I：

10.1351/pac199365061123

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The design, synthesis, and evaluation of DNA minor groove binding agents related to (+)-CC-1065 and (+)-duocarmycin A are detailed in continuing efforts to define the structural origin of the sequence-selective DNA alkylation reaction.

引用

页码：1123 / 1132

页数：10

共 32 条

[1] Boger D. L., 1991, CHEMTRACTS ORG CHEM, V4, P329
[2] DEMONSTRATION OF A PRONOUNCED EFFECT OF NONCOVALENT BINDING SELECTIVITY ON THE (+)-CC-1065 DNA ALKYLATION AND IDENTIFICATION OF THE PHARMACOPHORE OF THE ALKYLATION SUBUNIT
BOGER, DL
ZARRINMAYEH, H
MUNK, SA
KITOS, PA
SUNTORNWAT, O
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (04) : 1431 - 1435
[3] A DEMONSTRATION OF THE INTRINSIC IMPORTANCE OF STABILIZING HYDROPHOBIC BINDING AND NONCOVALENT VANDERWAALS CONTACTS DOMINANT IN THE NONCOVALENT CC-1065/B-DNA BINDING
BOGER, DL
INVERGO, BJ
COLEMAN, RS
ZARRINMAYEH, H
KITOS, PA
THOMPSON, SC
LEONG, T
MCLAUGHLIN, LW
[J]. CHEMICO-BIOLOGICAL INTERACTIONS, 1990, 73 (01) : 29 - 52
[4] (+)-CC-1065 DNA ALKYLATION - KEY STUDIES DEMONSTRATING A NONCOVALENT BINDING SELECTIVITY CONTRIBUTION TO THE ALKYLATION SELECTIVITY
BOGER, DL
MUNK, SA
ZARRINMAYEH, H
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (10) : 3980 - 3983
[5] SYNTHESIS OF N-(TERT-BUTYLOXYCARBONYL)-CBI, CBI, CBI-CDPI1, AND CBI-CDPI2 - ENHANCED FUNCTIONAL ANALOGS OF CC-1065 INCORPORATING THE 1,2,9,9A-TETRAHYDROCYCLOPROPA[C]BENZ[E]INDOL-4-ONE (CBI) LEFT-HAND SUBUNIT
BOGER, DL
ISHIZAKI, T
KITOS, PA
SUNTORNWAT, O
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (23) : 5823 - 5832
[6] SYNTHESIS AND PRELIMINARY EVALUATION OF AGENTS INCORPORATING THE PHARMACOPHORE OF THE DUOCARMYCIN PYRINDAMYCIN ALKYLATION SUBUNIT - IDENTIFICATION OF THE CC-1065 DUOCARMYCIN COMMON PHARMACOPHORE
BOGER, DL
ISHIZAKI, T
ZARRINMAYEH, H
KITOS, PA
SUNTORNWAT, O
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (15) : 4499 - 4502
[7] ISOLATION AND CHARACTERIZATION OF THE DUOCARMYCIN ADENINE DNA ADDUCT
BOGER, DL
ISHIZAKI, T
ZARRINMAYEH, H
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (17) : 6645 - 6649
[8] SYNTHESIS AND EVALUATION OF ABORTED AND EXTENDED CC-1065 FUNCTIONAL ANALOGS - (+)-CPI-PDE-I1, AND (-)-CPI-PDE-I1, (+)-CPI-PDE-I1, AND (-)-CPI-CDPI1, AND (+/-)-CPI-PDE-I1, (+)-CPI-PDE-I1, AND (-)-CPI-CDPI3 - PREPARATION OF KEY PARTIAL STRUCTURES AND DEFINITION OF AN ADDITIONAL FUNCTIONAL-ROLE OF THE CC-1065 CENTRAL AND RIGHT-HAND SUBUNITS
BOGER, DL
COLEMAN, RS
INVERGO, BJ
SAKYA, SM
ISHIZAKI, T
MUNK, SA
ZARRINMAYEH, H
KITOS, PA
THOMPSON, SC
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (12) : 4623 - 4632
[9] SYNTHESIS AND PRELIMINARY EVALUATION OF (+)-CBI-INDOLE2 - AN ENHANCED FUNCTIONAL ANALOG OF (+)-CC-1065
BOGER, DL
ISHIZAKI, T
SAKYA, SM
MUNK, SA
KITOS, PA
JIN, Q
BESTERMAN, JM
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1991, 1 (02) : 115 - 120
[10] DUOCARMYCIN PYRINDAMYCIN DNA ALKYLATION PROPERTIES AND IDENTIFICATION, SYNTHESIS, AND EVALUATION OF AGENTS INCORPORATING THE PHARMACOPHORE OF THE DUOCARMYCIN PYRINDAMYCIN ALKYLATION SUBUNIT - IDENTIFICATION OF THE CC-1065-DUOCARMYCIN COMMON PHARMACOPHORE
BOGER, DL
ISHIZAKI, T
ZARRINMAYEH, H
MUNK, SA
KITOS, PA
SUNTORNWAT, O
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (24) : 8961 - 8971

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